Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,651–19,675 of 27,380 studies, newest first · page 787 of 1096.
February 2012 23
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2012-02-03
Effects of ω-3 fatty acids on cognitive performance: a meta-analysis
65/100 ✓ Peer-reviewed Cognitive tests and assessment Neurobiology of aging
Key finding: Higher intake of omega-3 fatty acids (n-3 FAs) is associated with a reduced risk of Alzheimer's disease (AD) and milder forms of cognitive impairment (e.g. cognitive impairment no dementia [CIND]); however, findings from interventional trials are inconsistent. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-03
Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study
68/100 ✓ Peer-reviewed How common it is The Lancet. Neurology
Key finding: Patients with the repeat expansion had significantly more co-morbid FTD than patients without the repeat (50%vs 12%), and a distinct pattern of non-motor cortex changes on high-resolution 3 T magnetic resonance structural neuroimaging. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-03
Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis
62/100 ✓ Peer-reviewed Genetics The Lancet. Neurology
Key finding: We used Kaplan-Meier survival analysis to examine the distribution of incident ARIA-E from the start of bapineuzumab treatment and proportional hazards regression models to assess risk factors associated with ARIA. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-02
Glial cells in (patho)physiology
36/100 ✓ Peer-reviewed Disease mechanisms Journal of neurochemistry
Key finding: Once in the extracellular space, gliotransmitters can modulate synaptic plasticity and cause changes in behavior. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-02
Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia
47/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of biological chemistry
Key finding: Recent studies have demonstrated that a fraction of extracellular Aβ is associated with exosomes, small membrane vesicles of endosomal origin, although the fate of Aβ in association with exosome is largely unknown. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-02
Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations
60/100 ✓ Peer-reviewed How common it is Brain : a journal of neurology
Key finding: There was, as expected, a significant association between C9ORF72 mutations and presence of motor neuron disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-02
Automatic voxel-based morphometry of structural MRI by SPM8 plus diffeomorphic anatomic registration through exponentiated lie algebra improves the diagnosis of probable Alzheimer Disease
49/100 ✓ Peer-reviewed Brain scans and imaging AJNR. American journal of neuroradiology
Key finding: This software program with application of SPM8 plus DARTEL to VBM provides a high performance for AD diagnosis by using MRI.
Full summary, score breakdown and related studies → Original source
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2012-02-01
Red blood cell ω-3 fatty acid levels and markers of accelerated brain aging
60/100 ✓ Peer-reviewed Prevention trials Neurology
Key finding: Lower RBC DHA levels are associated with smaller brain volumes and a "vascular" pattern of cognitive impairment even in persons free of clinical dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-01
BACE1 dependent neuregulin processing: review
36/100 ✓ Peer-reviewed Treatments Current Alzheimer research
Key finding: Biochemical studies have shown that the precursor proteins of NRG1 can be released from the membrane through limited proteolysis. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-02-01
Subjective cognition and amyloid deposition imaging: a Pittsburgh Compound B positron emission tomography study in normal elderly individuals
52/100 ✓ Peer-reviewed Brain scans and imaging Archives of neurology
Key finding: A decrease of self-confidence about memory abilities in cognitively normal elderly subjects may be related to the neuropathological hallmark of AD measured with PiB-positron emission tomography. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-01
End-of-life care for people with dementia from ethnic minority groups: a systematic review
64/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: The qualitative evidence, albeit limited, found that attitudes toward end-of-life care were more similar than different between different ethnic groups. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-01
Poststroke delirium incidence and outcomes: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
64/100 ✓ Peer-reviewed Clinical safety Critical care medicine
Key finding: Measurements and main results Criterion validity and overall accuracy of the Czech version of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) were determined using serial daily delirium assessments with CAM-ICU by a junior physician compared with delirium diagnosis by delirium experts using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria that began the first day after stroke onset and continued for at least 7 days. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-02-01
Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic mice
36/100 ✓ Peer-reviewed Disease mechanisms Journal of neuropathology and experimental neurology
Key finding: We found that TBI resulted in abnormal axonal accumulation of several kinases that phosphorylate tau. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-02-01
Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
60/100 ✓ Peer-reviewed Disease mechanisms Neuron
Key finding: Tau pathology progresses from EC transgene-expressing neurons to neurons without detectable transgene expression, first to EC neighboring cells, followed by propagation to neurons downstream in the synaptic circuit such as the dentate gyrus, CA fields of the hippocampus, and cingulate cortex. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-01
Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families
59/100 ✓ Peer-reviewed Brain tissue and pathology PloS one
Key finding: Mutation screening in these genes has been performed in either very small series or in single families with late onset AD (LOAD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-01
Cerebrospinal fluid Aβ and tau level fluctuation in an older clinical cohort
45/100 ✓ Peer-reviewed Tau biomarkers Archives of neurology
Key finding: Biomarker validation in a clinical cohort. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-01
Age and diagnostic performance of Alzheimer disease CSF biomarkers
61/100 ✓ Peer-reviewed Tau biomarkers Neurology
Key finding: Core CSF changes in Alzheimer disease (AD) are decreased amyloid β(1-42), increased total tau, and increased phospho-tau, probably indicating amyloid plaque accumulation, axonal degeneration, and tangle pathology, respectively. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-01
Physiological functions of APP family proteins
45/100 ✓ Peer-reviewed Risk genes beyond APOE Cold Spring Harbor perspectives in medicine
Key finding: Biochemically, deposition of the β-amyloid (Aβ) peptides produced from proteolytic processing of APP forms the defining pathological hallmark of AD; genetically, both point mutations and duplications of wild-type APP are linked to a subset of early onset of familial AD (FAD) and cerebral amyloid angiopathy. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-01
Interventions for Hispanic caregivers of patients with dementia: a review of the literature
38/100 ✓ Peer-reviewed Disparities American journal of Alzheimer's disease and other dementias
Key finding: Future studies should consider culturally tailoring interventions for Hispanic/Latino caregivers from differing subcultures, utilizing relevant technology in studies, and evaluating the functional level of the care receiver and assess where he/she is in the disease process continuum. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-01
Accelerated cortical atrophy in cognitively normal elderly with high β-amyloid deposition
48/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Our findings show that the presence of Aβ in the brain, known to occur in about one-third of asymptomatic elderly individuals, is actually a pathologic state associated with accelerated atrophy. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-01
Posterior cortical atrophy
54/100 ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology
Key finding: The progressive neurodegeneration affecting parietal, occipital, and occipitotemporal cortices that underlies PCA is attributable to Alzheimer's disease in most patients. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-01
Exergaming and older adult cognition: a cluster randomized clinical trial
70/100 ✓ Peer-reviewed Prevention and risk American journal of preventive medicine
Key finding: Cybercycling older adults achieved better cognitive function than traditional exercisers, for the same effort, suggesting that simultaneous cognitive and physical exercise has greater potential for preventing cognitive decline. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-01
β-Amyloid burden in healthy aging: regional distribution and cognitive consequences
57/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Even in a highly selected lifespan sample of adults, Aβ deposition is apparent in some adults and is influenced by APOE status. +4 more findings
Full summary, score breakdown and related studies → Original source
January 2012 2
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2012-01-30
Spatial navigation impairment is proportional to right hippocampal volume
43/100 ✓ Peer-reviewed Hippocampus size on brain scans Proceedings of the National Academy of Sciences of the United States of America
Key finding: We found that smaller right hippocampal volume was associated with poorer navigation performance in both the real-space (β = -0.62, P < 0.001) and virtual (β = -0.43, P = 0.026) versions, controlling for demographic variables, total brain and left hippocampal volumes. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-01-30
Maternal support in early childhood predicts larger hippocampal volumes at school age
52/100 ✓ Peer-reviewed Hippocampus size on brain scans Proceedings of the National Academy of Sciences of the United States of America
Key finding: In humans, a relationship between psychosocial factors in early childhood and later amygdala volumes based on prospective data has been demonstrated, providing a key link between early experience and brain development. +1 more finding
Full summary, score breakdown and related studies → Original source
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