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Cerebral amyloid angiopathy in the elderly
Viswanathan A, Greenberg SM.. Annals of neurology, 2011-12-01
Topic: Amyloid, tau and blood-test diagnosis
Cerebral amyloid angiopathy (CAA) results from deposition of β-amyloid in the media and adventitia of small arteries and capillaries of the leptomeninges and cerebral cortex and is a major cause of lobar intracerebral hemorrhage and cognitive impairment in the elderly. CAA is associated with a high prevalence of magnetic resonance imaging markers of small vessel disease, including cerebral microbleeds and white matter hyperintensities. Although advanced CAA is present in approximately ¼ of brains with Alzheimer disease (AD), fewer than half of CAA cases meet pathologic criteria for AD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Viswanathan, A., & Greenberg, S. M. (2011). Cerebral amyloid angiopathy in the elderly. Annals of neurology. https://doi.org/10.1002/ana.22516
Vancouver
Viswanathan A, Greenberg SM. Cerebral amyloid angiopathy in the elderly. Annals of neurology. 2011. doi:10.1002/ana.22516. PMID: 22190361.
BibTeX
@article{viswanathan2011-22190361,
author = {Viswanathan, A. and Greenberg, S. M.},
title = {{Cerebral amyloid angiopathy in the elderly}},
journal = {Annals of neurology},
year = {2011},
doi = {10.1002/ana.22516},
pmid = {22190361},
url = {https://doi.org/10.1002/ana.22516}
}
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Key findings
- CAA is associated with a high prevalence of magnetic resonance imaging markers of small vessel disease, including cerebral microbleeds and white matter hyperintensities.
- Although advanced CAA is present in approximately ¼ of brains with Alzheimer disease (AD), fewer than half of CAA cases meet pathologic criteria for AD.
- This review will discuss the pathophysiology of CAA and focus on new imaging modalities and laboratory biomarkers that may aid in the clinical diagnosis of individuals with the disease.
Why it matters
This review discusses cerebral amyloid angiopathy, which results from beta-amyloid deposition in small arteries and capillaries of the brain and is a major cause of lobar intracerebral hemorrhage and cognitive impairment in the elderly. Advanced CAA is present in approximately one-quarter of brains with Alzheimer's disease, but fewer than half of CAA cases meet pathologic criteria for Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 55/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of neurology) |
| Journal's citation record | 3 / 4 | Annals of Neurology: journal h-index 437 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 639 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 37.6 citations a year over 17 year(s) since 2011 |
| Impact for its field and year | 4 / 6 | Cited 18.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 32 other studies in this library |
| Still being cited | 3 / 4 | Cited 123 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Steven Mark Greenberg: h-index 144 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 22190361) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 55 / 100 | — |
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