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Biological age acceleration associates with Alzheimer's disease plasma biomarker levels
Jaclyn M Eissman, Yiyi Ma, Min Qiao, Dolly Reyes-Dumeyer, Angel Piriz, Annie J Lee, Rafael A Lantigua, Martin Medrano et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026-01
Topic: Plasma and spinal-fluid biomarkers
Age acceleration was significantly associated with sex, clinical diagnosis, and levels of eight plasma biomarkers, including P-tau217 levels. Additionally, biomarker associations trended more significantly among APOE-ε4 non-carriers. We also identified that methylation levels in CD4 and CD8 T-cell types are associated with age acceleration. We demonstrated that biological age acceleration, measured in blood, in a Hispanic cohort enriched for preclinical individuals, can stratify clinical AD risk and is associated with plasma AD biomarker levels. HIGHLIGHTS: Blood-based aging clocks associate with Alzheimer's disease plasma biomarker levels. Biological aging appears relevant to pathological aging in apolipoprotein E (APOE) -ε4 non-carriers. Immune T-cell composition relates to biological aging.
Key findings
- Age acceleration was significantly associated with sex, clinical diagnosis, and levels of eight plasma biomarkers, including P-tau217 levels.
- Additionally, biomarker associations trended more significantly among APOE-ε4 non-carriers.
- We also identified that methylation levels in CD4 and CD8 T-cell types are associated with age acceleration.
- We demonstrated that biological age acceleration, measured in blood, in a Hispanic cohort enriched for preclinical individuals, can stratify clinical AD risk and is associated with plasma AD biomarker levels.
- HIGHLIGHTS: Blood-based aging clocks associate with Alzheimer's disease plasma biomarker levels.
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Study details
- Evidence strengthModerate
How this study scored 52/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 29 of the 56 points we could judge it on, which is 52 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41572665) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 29 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 29 of the 56 points we could judge it on is 52 out of 100. |
| Total | 52 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Eissman, J. M., Ma, Y., Qiao, M., Reyes-Dumeyer, D., Piriz, A., Lee, A. J., et al. (2026). Biological age acceleration associates with Alzheimer's disease plasma biomarker levels. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.71005
Vancouver
Eissman JM, Ma Y, Qiao M, Reyes-Dumeyer D, Piriz A, Lee AJ, et al. Biological age acceleration associates with Alzheimer's disease plasma biomarker levels. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026. doi:10.1002/alz.71005. PMID: 41572665.
BibTeX
@article{eissman2026-41572665,
author = {Eissman, Jaclyn M and Ma, Yiyi and Qiao, Min and Reyes-Dumeyer, Dolly and Piriz, Angel and Lee, Annie J and Lantigua, Rafael A and Medrano, Martin and others},
title = {{Biological age acceleration associates with Alzheimer's disease plasma biomarker levels}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
doi = {10.1002/alz.71005},
pmid = {41572665},
url = {https://doi.org/10.1002/alz.71005}
}
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