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Diagnostic accuracy of the MMSE in detecting probable and possible Alzheimer's disease in ethnically diverse highly educated individuals: an analysis of the NACC database
Spering CC, Hobson V, Lucas JA, Menon CV, Hall JR, O'Bryant SE.. The journals of gerontology. Series A, Biological sciences and medical sciences, 2012-03-06
Topic: Amyloid, tau and blood-test diagnosis
Background To validate and extend the findings of a raised cut score of O'Bryant and colleagues (O'Bryant SE, Humphreys JD, Smith GE, et al. Detecting dementia with the mini-mental state examination in highly educated individuals. Arch Neurol. 2008;65(7):963-967.) for the Mini-Mental State Examination in detecting cognitive dysfunction in a bilingual sample of highly educated ethnically diverse individuals.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Spering, C. C., Hobson, V., Lucas, J. A., Menon, C. V., Hall, JR., & O'Bryant, S. E. (2012). Diagnostic accuracy of the MMSE in detecting probable and possible Alzheimer's disease in ethnically diverse highly educated individuals: an analysis of the NACC database. The journals of gerontology. Series A, Biological sciences and medical sciences. https://doi.org/10.1093/gerona/gls006
Vancouver
Spering CC, Hobson V, Lucas JA, Menon CV, Hall JR, O'Bryant SE. Diagnostic accuracy of the MMSE in detecting probable and possible Alzheimer's disease in ethnically diverse highly educated individuals: an analysis of the NACC database. The journals of gerontology. Series A, Biological sciences and medical sciences. 2012. doi:10.1093/gerona/gls006. PMID: 22396476.
BibTeX
@article{spering2012-22396476,
author = {Spering, C. C. and Hobson, V. and Lucas, J. A. and Menon, C. V. and Hall, JR. and O'Bryant, S. E.},
title = {{Diagnostic accuracy of the MMSE in detecting probable and possible Alzheimer's disease in ethnically diverse highly educated individuals: an analysis of the NACC database}},
journal = {The journals of gerontology. Series A, Biological sciences and medical sciences},
year = {2012},
doi = {10.1093/gerona/gls006},
pmid = {22396476},
url = {https://doi.org/10.1093/gerona/gls006}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Detecting dementia with the mini-mental state examination in highly educated individuals.
- Arch Neurol. 2008;65(7):963-967.) for the Mini-Mental State Examination in detecting cognitive dysfunction in a bilingual sample of highly educated ethnically diverse individuals.
- Methods Archival data were reviewed from participants enrolled in the National Alzheimer's Coordinating Center minimum data set.
- Data on 7,093 individuals with 16 or more years of education were analyzed, including 2,337 cases with probable and possible Alzheimer's disease, 1,418 mild cognitive impairment patients, and 3,088 nondemented controls.
Why it matters
This analysis looked at whether the Mini-Mental State Examination detects cognitive dysfunction accurately in highly educated, ethnically diverse people. It used existing data from 7,093 individuals with 16 or more years of education, so it concerns diagnosis rather than treatment, cure or prevention.
Study details
- Participants7,093
- Evidence strengthModerate
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The journals of gerontology. Series A, Biological sciences and medical sciences) |
| Journal's citation record | 3 / 4 | The Journals of Gerontology Series A: journal h-index 274 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2012 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 7,093 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 110 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 6.9 citations a year over 16 year(s) since 2012 |
| Impact for its field and year | 3 / 6 | Cited 4.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 7 other studies in this library |
| Still being cited | 2 / 4 | Cited 18 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Sid E. O’Bryant: h-index 63 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Texas Tech University: institution h-index 686 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 22396476) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
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