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P3‐402: Detection of PCC functional connectivity characteristics in subcortical vascular mild cognitive impairment: A resting‐state fMRI study
Han Yin, Liye Yi, Jinhui Wang. Alzheimer s & Dementia, 2012-07-01
Topic: Brain proteins, microglia and lab models
Subcortical vascular mild cognitive impairment (svMCI) is known to be a prodromal stage of subcortical vascular dementia (SVaD) (1-3) who may also developed to mixed Alzheimer's disease (AD) (4). Based on position emission tomography (PET) (5) and structural MRI (sMRI) (3) data sets, neuroimaging studies showed that functional and structural deficits in the cortical brain regions [e.g., the medial frontal cortex, the posterior cingulate cortex (PCC) and the medial temporal lobe] and the subcortical brain regions (e.g., the thalamus and the caudate) in svMCI. Increasing evidence from diffusion tensor imaging (DTI) studies (6, 7) suggested that these locally deficits might arise from disturbances of fiber connections. To explore the brain network deficits in svMCI, we employed the regions of interest (ROI) based functional connectivity (FC) method investigating FC alterations in the svMCI patients. Fifty-four right-handed participants, including 26 svMCI patients and 28 healthy controls (HC) participated in this study. The recruited patients were outpatients who were registered at the neurology department of Xuanwu Hospital, Capital Medical University, Beijing, China. All images were acquired using a 3.0 T Siemens scanner at Xuanwu Hospital, Capital Medical University. Functional MRI data was preprocessed usingSPM5 package (http://www.fil.ion.ucl.ac.uk/spm), including slice timing, head motion correction, spatial normalization (through structural images), spatial smoothing (radius = 6mm) and temporal filtering (0.01 - 0.08 Hz). The resultant functional images were subject to voxel based Functional connectivity computation using REST software (www.restfmri.net) with the PCC (0,-52,22; radius = 5mm) as the ROI. Then, a Fisher z-transform was applied to normalize the correlation coefficients. To determine between-group differences in FC, multiple linear regression analyses were separately performed with age, gender and years of education as covariates. All results were presented at the statistical threshold of P < 0.05 for individual voxel combined with P < 0.05 for spatial cluster size determined by Monte Carlo simulations (8). Compared with normal controls, widespread PCC related functional connectivity changes were found in the svMCI patients.
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APA 7th
Yin, H., Yi, L., & Wang, J. (2012). P3‐402: Detection of PCC functional connectivity characteristics in subcortical vascular mild cognitive impairment: A resting‐state fMRI study. Alzheimer s & Dementia. https://doi.org/10.1016/j.jalz.2012.05.2076
Vancouver
Yin H, Yi L, Wang J. P3‐402: Detection of PCC functional connectivity characteristics in subcortical vascular mild cognitive impairment: A resting‐state fMRI study. Alzheimer s & Dementia. 2012. doi:10.1016/j.jalz.2012.05.2076.
BibTeX
@article{yin2012-650c2de6,
author = {Yin, Han and Yi, Liye and Wang, Jinhui},
title = {{P3‐402: Detection of PCC functional connectivity characteristics in subcortical vascular mild cognitive impairment: A resting‐state fMRI study}},
journal = {Alzheimer s \& Dementia},
year = {2012},
doi = {10.1016/j.jalz.2012.05.2076},
url = {https://doi.org/10.1016/j.jalz.2012.05.2076}
}
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Key findings
- Based on position emission tomography (PET) (5) and structural MRI (sMRI) (3) data sets, neuroimaging studies showed that functional and structural deficits in the cortical brain regions [e.g., the medial frontal cortex, the posterior cingulate cortex (PCC) and the medial temporal lobe] and the subcortical brain regions (e.g., the thalamus and the caudate) in svMCI.
- Increasing evidence from diffusion tensor imaging (DTI) studies (6, 7) suggested that these locally deficits might arise from disturbances of fiber connections.
- All results were presented at the statistical threshold of P < 0.05 for individual voxel combined with P < 0.05 for spatial cluster size determined by Monte Carlo simulations (8).
- Compared with normal controls, widespread PCC related functional connectivity changes were found in the svMCI patients.
Why it matters
This small study of 26 patients with subcortical vascular mild cognitive impairment and 28 healthy controls used resting-state functional MRI to examine brain connectivity. The findings are preliminary and do not establish any treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 29/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2012 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 16 year(s) since 2012 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Jinhui Wang: h-index 54 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Capital Medical University: institution h-index 643 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Total | 29 / 100 | — |
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