Newest studies

Diabetes drugs and neurological disorders: new views and therapeutic possibilities

36/100 ✓ Peer-reviewed Drug development The lancet. Diabetes & endocrinology

Key finding: It is associated with increased risk of stroke and vascular dementia, and might contribute to the development of Alzheimer's disease. +2 more findings

• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

Drosophila melanogaster as a model organism for Alzheimer's disease

40/100 ✓ Peer-reviewed Brain scans and imaging Molecular neurodegeneration

Key finding: Overexpression of human wild-type or mutant Tau causes age-dependent neurodegeneration, axonal transport defects and early death. +4 more findings

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Racial/ethnic differences in dementia risk among older type 2 diabetic patients: the diabetes and aging study

51/100 ✓ Peer-reviewed Disparities Diabetes care

Key finding: Among type 2 diabetic patients followed for 10 years, African Americans and Native Americans had a 40-60% greater risk of dementia compared with Asians, and risk was intermediate for non-Hispanic whites and Latinos. +2 more findings

• Health Equity
• Risk Factors

Full summary, score breakdown and related studies → Original source

LIM homeobox 8 (Lhx8) is a key regulator of the cholinergic neuronal function via a tropomyosin receptor kinase A (TrkA)-mediated positive feedback loop

37/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of biological chemistry

Key finding: Together, our findings suggest that positive feedback regulation between Lhx8, TrkA, and NGF is an important regulatory mechanism for cholinergic functions of the septum.

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Investigation of triggering receptor expressed on myeloid cells 2 variant in the Wisconsin Registry for Alzheimer's Prevention

64/100 ✓ Peer-reviewed TREM2 and immune genetics Neurobiology of aging

Key finding: There was no significant association between TREM2 carrier status and cognitive function or decline. +1 more finding

• Genetics
• Prevention

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Non-specialist health worker interventions for the care of mental, neurological and substance-abuse disorders in low- and middle-income countries

68/100 ✓ Peer-reviewed Caregiving The Cochrane database of systematic reviews

Key finding: Where feasible, we combined data to obtain an overall estimate of effect. +3 more findings

• Health Equity

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A brain-computer interface based cognitive training system for healthy elderly: a randomized control pilot study for usability and preliminary efficacy

74/100 ✓ Peer-reviewed Prevention trials PloS one

Key finding: Cognitive decline in aging is a pressing issue associated with significant healthcare costs and deterioration in quality of life. +3 more findings

• Clinical Trials

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RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia

57/100 ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America

Key finding: Previously, we showed that microsatellite expansion mutations can be bidirectionally transcribed and that these mutations express unexpected proteins by a unique mechanism, repeat-associated non-ATG (RAN) translation. +2 more findings

• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Positive effects of resistance training in frail elderly patients with dementia after long-term physical restraint

36/100 ✓ Peer-reviewed Clinical safety Age (Dordrecht, Netherlands)

Key finding: After the first 4 weeks of training, there was a significant improvement only in the balance test, whereas no additional changes were observed. +2 more findings

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Profile of gantenerumab and its potential in the treatment of Alzheimer's disease

38/100 ✓ Peer-reviewed Treatments Drug design, development and therapy

Key finding: Alzheimer's disease, which is characterized by gradual cognitive decline associated with deterioration of daily living activities and behavioral disturbances throughout the course of the disease, is estimated to affect 27 million people around the world.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions

45/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: Accumulation of Aβ and in particular Aβ42 is enhanced by familial Alzheimer disease (FAD) causing mutations in APP and is believed to play a pivotal role. +3 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Pulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults

49/100 ✓ Peer-reviewed Genetics Neurology

Key finding: The relationship between PP and CSF biomarkers is age-dependent and observed only in participants in the fifth and sixth decades of life.

• Biomarkers
• Genetics
• Early Stage

Full summary, score breakdown and related studies → Original source

Abnormal salience network in normal aging and in amnestic mild cognitive impairment and Alzheimer's disease

46/100 ✓ Peer-reviewed Mild cognitive impairment Human brain mapping

Key finding: All the SN components showed significant differences in the GMV, intranetwork FC, and internetwork FC between the HYC and HOC. +2 more findings

• Early Stage

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Reasons for institutionalization of people with dementia: informal caregiver reports from 8 European countries

49/100 ✓ Peer-reviewed Caregiving Journal of the American Medical Directors Association

Key finding: Multiple reasons contribute to the institutionalization for people with dementia, with several factors that may influence why there were country differences. +2 more findings

• Caregiving

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Transmission of multiple system atrophy prions to transgenic mice

52/100 ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America

Key finding: Our results provide compelling evidence that α-synuclein aggregates formed in the brains of MSA patients are transmissible and, as such, are prions.

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Nonamnestic mild cognitive impairment progresses to dementia with Lewy bodies

57/100 ✓ Peer-reviewed Mild cognitive impairment Neurology

Key finding: In a clinical sample, patients with nonamnestic MCI were more likely to develop DLB, and those with amnestic MCI were more likely to develop probable AD.

• Other Dementias
• Early Stage

Full summary, score breakdown and related studies → Original source

Alzheimer's disease: analyzing the missing heritability

52/100 ✓ Peer-reviewed Genetics PloS one

Key finding: Based on our findings and the current direction of human genetics research, we suggest specific study designs for future studies to identify the remaining heritability of Alzheimer's disease.

• Genetics

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Autophagy and apoptosis dysfunction in neurodegenerative disorders

36/100 ✓ Peer-reviewed Disease mechanisms Progress in neurobiology

Key finding: They have to be seen not only as a health problem, but since they are care-intensive, they also carry a significant economic burden.

• Other Dementias

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Quantitative Analysis of PiB-PET with FreeSurfer ROIs

48/100 ✓ Peer-reviewed Brain scans and imaging PLoS ONE

In vivo quantification of β-amyloid deposition using positron emission tomography is emerging as an important procedure for the early diagnosis of the Alzheimer's disease and is likely to play an important role in upcoming clinical trials of disease modifying agents.

• Brain Scans

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Bilingualism delays age at onset of dementia, independent of education and immigration status

56/100 ✓ Peer-reviewed Disparities Neurology

Key finding: This is the largest study so far documenting a delayed onset of dementia in bilingual patients and the first one to show it separately in different dementia subtypes. +2 more findings

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Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease

52/100 ✓ Peer-reviewed Brain scans and imaging Proceedings of the National Academy of Sciences of the United States of America

Key finding: Additional analyses of individuals in which longitudinal data were available suggested that an accelerated appearance of volumetric declines approximately coincides with the onset of the symptomatic phase of the disease.

• Brain Scans
• Genetics
• Biomarkers

Full summary, score breakdown and related studies → Original source

SET translocation is associated with increase in caspase cleaved amyloid precursor protein in CA1 of Alzheimer and Down syndrome patients

39/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of aging

Key finding: These data suggest that increase in APPcc in CA1 neurons could be an early event leading to the translocation of SET and the progression of AD through tau hyperphosphorylation.

• Down Syndrome

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Roles of vascular and metabolic components in cognitive dysfunction of Alzheimer disease: short- and long-term modification by non-genetic risk factors

41/100 ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

Key finding: Non-genetic risk factors also modify the pathological manifestations of AD in the long-term. +4 more findings

• Risk Factors
• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

Bilingualism does not alter cognitive decline or dementia risk among Spanish-speaking immigrants

54/100 ✓ Peer-reviewed Disparities Neuropsychology

Key finding: This study does not support a protective effect of bilingualism on age-related cognitive decline or the development of dementia. +3 more findings

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Reduced FDG-PET brain metabolism and executive function predict clinical progression in elderly healthy subjects

47/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage. Clinical

Key finding: Lower FDG-PET ROI values were associated with higher likelihood of conversion (p = 0.004), with the area under the curve (AUC) yielding 82.0% (95% CI = (95.5%, 68.5%)). +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source