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Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions
Biessels GJ, Strachan MW, Visseren FL, Kappelle LJ, Whitmer RA.. The lancet. Diabetes & endocrinology, 2013-10-18
Topic: Risk, prevention and care in population studies
Type 2 diabetes is associated with dementia, and also with more slight cognitive decrements. In this Review we discuss trajectories from normal cognition to dementia in people with type 2 diabetes, and explore opportunities for treatment. Slight diabetes-associated cognitive decrements and dementia affect different age groups and show a different evolution. These cognitive entities should therefore not be regarded as a continuum, although their effects might be additive. Vascular damage is a key underlying process in both entities. Glucose-mediated processes and other metabolic disturbances might also have a role. No treatment has been established, but management of vascular risk factors and optimisation of glycaemic control could have therapeutic benefit. We identify possible opportunities for intervention to improve cognitive outcomes in people with type 2 diabetes, and suggest how treatment can be tailored to individual risk profiles and comorbidities.
Key findings
- Type 2 diabetes is associated with dementia, and also with more slight cognitive decrements.
Why it matters
This review states that type 2 diabetes is associated with dementia and with more slight cognitive decrements, and that vascular damage is a key underlying process in both. It notes no treatment has been established, but that management of vascular risk factors and optimisation of glycaemic control could have therapeutic benefit.
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Study details
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The lancet. Diabetes & endocrinology) |
| Journal's citation record | 3 / 4 | The Lancet Diabetes & Endocrinology: journal h-index 250 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 552 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 39.4 citations a year over 14 year(s) since 2014 |
| Impact for its field and year | 4 / 6 | Cited 14.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 19 other studies in this library |
| Still being cited | 3 / 4 | Cited 109 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Rachel A. Whitmer: h-index 63 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Utrecht University: institution h-index 1,157 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24622755) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 50 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Biessels, G. J., Strachan, M. W., Visseren, F. L., Kappelle, L. J., & Whitmer, R. A. (2014). Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions. The lancet. Diabetes & endocrinology. https://doi.org/10.1016/s2213-8587(13)70088-3
Vancouver
Biessels GJ, Strachan MW, Visseren FL, Kappelle LJ, Whitmer RA. Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions. The lancet. Diabetes & endocrinology. 2014. doi:10.1016/s2213-8587(13)70088-3. PMID: 24622755.
BibTeX
@article{biessels2014-24622755,
author = {Biessels, G. J. and Strachan, M. W. and Visseren, F. L. and Kappelle, L. J. and Whitmer, R. A.},
title = {{Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions}},
journal = {The lancet. Diabetes \& endocrinology},
year = {2014},
doi = {10.1016/s2213-8587(13)70088-3},
pmid = {24622755},
url = {https://doi.org/10.1016/s2213-8587(13)70088-3}
}
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