Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,301–18,325 of 27,380 studies, newest first · page 733 of 1096.
November 2013 13
-
2013-11-01
Susceptibility to mortality in weather extremes: effect modification by personal and small-area characteristics
64/100 ✓ Peer-reviewed Costs and economics Epidemiology (Cambridge, Mass.)
Key finding: We identified several subgroups of the population who are particularly susceptible to temperature extremes, including persons with atrial fibrillation. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2013-11-01
Oxidative stress and mitochondrial dysfunction in Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms Biochimica et biophysica acta
Key finding: Alzheimer's disease (AD) exhibits extensive oxidative stress throughout the body, being detected peripherally as well as associated with the vulnerable regions of the brain affected in disease. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2013-11-01
Statins and cognitive function: a systematic review
67/100 ✓ Peer-reviewed Drug development Annals of internal medicine
Key finding: Larger and better-designed studies are needed to draw unequivocal conclusions about the effect of statins on cognition.
Full summary, score breakdown and related studies → Original source
-
2013-11-01
SQSTM1 mutations in French patients with frontotemporal dementia or frontotemporal dementia with amyotrophic lateral sclerosis
43/100 ✓ Peer-reviewed Genetics JAMA neurology
Key finding: Although the frequency of the mutations is low in our series (4 of 188 patients [2%]), our results, similar to those already reported, support a direct pathogenic role of p62 in different types of FTD. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2013-11-01
Loss of fornix white matter volume as a predictor of cognitive impairment in cognitively normal elderly individuals
64/100 ✓ Peer-reviewed Hippocampus size on brain scans JAMA neurology
Key finding: Fornix body volume and axial diffusivity were highly significant predictors (P = .02 and .005, respectively) of cognitive decline from normal cognition. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2013-11-01
In contrast to many other mammals, cetaceans have relatively small hippocampi that appear to lack adult neurogenesis
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Brain structure & function
Key finding: We identified that the hippocampus in cetaceans (whales, dolphins and porpoises) is both absolutely and relatively small for their overall brain size, and found that the mammalian hippocampus scaled as an exponential function in relation to brain volume. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2013-11-01
A novel prion disease associated with diarrhea and autonomic neuropathy
57/100 ✓ Peer-reviewed Disease mechanisms The New England journal of medicine
Key finding: Abnormal forms of prion protein that were found in multiple peripheral tissues were associated with diarrhea, autonomic failure, and neuropathy. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2013-11-01
TDP-43 pathology, cognitive decline, and dementia in old age
64/100 ✓ Peer-reviewed Brain tissue and pathology JAMA neurology
Key finding: Cognitive decline is a leading cause of disability and death in old age but its neurobiological bases are not well understood. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2013-11-01
Risk factors for the progression of mild cognitive impairment to dementia
44/100 ✓ Peer-reviewed Caregiving Clinics in geriatric medicine
Key finding: The increasing prevalence of cognitive impairment among the older adult population warrants attention to the identification of practices that may minimize the progression of early forms of cognitive impairment, including the transitional stage of mild cognitive impairment (MCI), to permanent stages of dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2013-11-01
Screening for cognitive impairment in older adults: A systematic review for the U.S. Preventive Services Task Force
62/100 ✓ Peer-reviewed Getting a diagnosis Annals of internal medicine
Key finding: Brief instruments to screen for cognitive impairment can adequately detect dementia, but there is no empirical evidence that screening improves decision making.
Full summary, score breakdown and related studies → Original source
-
2013-11-01
Classification and epidemiology of MCI
49/100 ✓ Peer-reviewed Getting a diagnosis Clinics in geriatric medicine
Key finding: Mild cognitive impairment (MCI) is an intermediate stage in the trajectory from normal cognition to dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2013-11-01
Risk factors for community-acquired pneumonia in adults in Europe: a literature review
52/100 ✓ Peer-reviewed Prevention and risk Thorax
Key finding: A range of lifestyle factors and underlying medical conditions are associated with an increased risk of CAP in European adults. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2013-11-01
The pathobiology of vascular dementia
56/100 ✓ Peer-reviewed Prevention and risk Neuron
Key finding: Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to full-blown dementia, attributable to cerebrovascular causes. +4 more findings
Full summary, score breakdown and related studies → Original source
October 2013 12
-
2013-10-30
Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation
36/100 ✓ Peer-reviewed Drug development Neuroscience
Key finding: We have previously demonstrated that glucagon-like peptide-1 (GLP-1) receptor agonist ameliorated neurodegenerative changes in rat models of diabetes-related Alzheimer's disease (AD), and protected neurons from glucose toxicity in vitro. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2013-10-30
Reduced CSF p-Tau181 to Tau ratio is a biomarker for FTLD-TDP
53/100 ✓ Peer-reviewed Tau biomarkers Neurology
Key finding: Antemortem CSF samples were collected from 30 patients with FTLD in a single-center validation cohort, and CSF levels of 5 putative FTLD-TDP biomarkers as well as levels of total Tau (t-Tau) and Tau phosphorylated at threonine 181 (p-Tau181) were measured using independent assays. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2013-10-29
Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808
48/100 ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer s Disease
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
-
2013-10-29
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration
53/100 ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America
Key finding: Antisense oligonucleotides (ASOs) are identified that reduce GGGGCC-containing nuclear foci without altering overall C9orf72 RNA levels. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2013-10-28
Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress
36/100 ✓ Peer-reviewed Drug development Journal of neurochemistry
Key finding: Glucagon-like peptide 1 (GLP-1) is a growth factor that has demonstrated neuroprotective properties in a range of studies. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2013-10-27
Cerebrospinal fluid τ protein in differential diagnosis of Alzheimer's disease and vascular dementia in Chinese population: a meta-analysis
66/100 ✓ Peer-reviewed Tau biomarkers American journal of Alzheimer's disease and other dementias
Key finding: Patients with AD exhibit significantly higher CSF τ protein levels than healthy controls or patients with VaD in the Chinese population. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2013-10-27
The microglial sensome revealed by direct RNA sequencing
59/100 ✓ Peer-reviewed Inflammation and the immune system Nature Neuroscience
Key finding: Microglia have a distinct transcriptomic signature and express a unique cluster of transcripts encoding proteins for sensing endogenous ligands and microbes, referred to as the sensome. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2013-10-27
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
66/100 ✓ Peer-reviewed Risk genes beyond APOE Nature Genetics
Researchers conducted a large, two-stage meta-analysis of genome-wide association studies in individuals of European ancestry.
Full summary, score breakdown and related studies → Original source
-
2013-10-27
The Alzheimer Conundrum
41/100 ✓ Peer-reviewed Risk factors Not indexed
Key finding: Based on a meticulous account of the history of Alzheimer's disease and extensive in-depth interviews, the book highlights the limitations and the dissent associated with biomarker detection.
Full summary, score breakdown and related studies → Original source
-
2013-10-26
A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II
65/100 ✓ Peer-reviewed How common it is The Lancet
Key finding: Age-standardized dementia prevalence fell from 8.3% (1991) to 6.5% (2011), OR 0.7 (95% CI 0.6-0.9, P=.003) +3 more findings
Full summary, score breakdown and related studies → Original source
-
2013-10-25
Compensatory changes in cortical resource allocation in adults with hearing loss
42/100 ✓ Peer-reviewed Digital health tools Frontiers in systems neuroscience
Key finding: However, it remains unclear whether cortical re-organization associated with hearing loss occurs in early stages of hearing decline and in early stages of auditory processing. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2013-10-24
Sleep apnea and the risk of dementia: a population-based 5-year follow-up study in Taiwan
71/100 ✓ Peer-reviewed Costs and economics PloS one
Key finding: SA may be a gender-dependent, age-dependent, and time-dependent risk factor for dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →