Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,551–24,575 of 27,380 studies, newest first · page 983 of 1096.
March 2003 24
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2003-03-01
Neurodegenerative diseases and exposure to pesticides in the elderly
52/100 ✓ Peer-reviewed Risk factors American journal of epidemiology
Key finding: These results suggest the presence of neurologic impairments in elderly persons who were exposed occupationally to pesticides.
Full summary, score breakdown and related studies → Original source
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2003-03-01
Protein carbonyl groups as biomarkers of oxidative stress
36/100 ✓ Peer-reviewed Risk factors Clinica chimica acta; international journal of clinical chemistry
Key finding: Among these diseases are those in which high levels of protein carbonyl (CO) groups have been observed, including Alzheimer's disease (AD), rheumatoid arthritis, diabetes, sepsis, chronic renal failure, and respiratory distress syndrome. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-03-01
The effects of improving hearing in dementia
36/100 ✓ Peer-reviewed Risk factors Age and ageing
Key finding: Measures of cognition and psychiatric symptoms, activities of daily living, and burden on carers were made over 6 months. +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-03-01
Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders
36/100 ✓ Peer-reviewed Genetics Brain research
Key finding: An increasing body of evidence indicates that oxidative stress and damage play a role in the pathogenesis of a number of diseases associated with neurodegeneration, including Down syndrome (DS), Alzheimer's disease (AD) and Pick's disease (PD). +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-03-01
APP processing and synaptic function
36/100 ✓ Peer-reviewed Risk genes beyond APOE Neuron
Key finding: In turn, Abeta selectively depresses excitatory synaptic transmission onto neurons that overexpress APP, as well as nearby neurons that do not. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-03-01
Association between dementia and midlife risk factors: the Radiation Effects Research Foundation Adult Health Study
52/100 ✓ Peer-reviewed Vascular contributions Journal of the American Geriatrics Society
Key finding: Increased SBP and low milk intake in midlife were associated with VaD detected 25 to 30 years later. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-03-01
Hippocampal sclerosis is a progressive disorder: a longitudinal volumetric MRI study
40/100 ✓ Peer-reviewed Hippocampus size on brain scans Annals of neurology
Key finding: Twelve patients with refractory temporal lobe epilepsy and unilateral hippocampal sclerosis had repeat volumetric magnetic resonance imaging scans after a mean of 3.4 years to determine whether progressive hippocampal volume loss occurred. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-03-01
PET imaging of 5-HT1A receptor binding in patients with temporal lobe epilepsy
47/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurology
Key finding: These findings support the hypothesis of reduced serotonin receptor binding in temporal lobe epileptic foci. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-03-01
Predictors of six-month survival among patients with dementia: an evaluation of hospice Medicare guidelines
60/100 ✓ Peer-reviewed End-of-life care The American journal of hospice & palliative care
Key finding: The Kaplan-Meier estimation of survival and a Cox regression analysis (p > 0. 05) revealed no significant relationship between the Medicare guidelines or any component of the guidelines and survival at six months for the initial and validation samples. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-03-01
Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes
36/100 ✓ Peer-reviewed Inflammation and the immune system Glia
Key finding: We found that QUIN induces astrocytes to produce large quantities of MCP-1 (CCL2) and lesser amounts of RANTES (CCL5) and IL-8 (CXCL8). +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-03-01
Fitness effects on the cognitive function of older adults: a meta-analytic study
53/100 ✓ Peer-reviewed Prevention and risk Psychological Science
A meta-analytic study was conducted to examine the hypothesis that aerobic fitness training enhances the cognitive vitality of healthy but sedentary older adults.
Full summary, score breakdown and related studies → Original source
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2003-03-01
17beta-estradiol reduces plasma Abeta40 for HRT-naïve postmenopausal women with Alzheimer disease: a preliminary study
56/100 ✓ Peer-reviewed Risk genes beyond APOE The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: These results provide preliminary clinical evidence to support an effect of estradiol on Abeta-processing for AD women who are HRT-naïve. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-03-01
Immune reactive cells in senile plaques and cognitive decline in Alzheimer's disease
45/100 ✓ Peer-reviewed Inflammation and the immune system Neurobiology of aging
Key finding: By measuring the fractional area (FA) of immunoreactivity, we found that Abeta deposits appear early in the pathogenesis of Abeta, but cannot account for cognitive decline. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-03-01
Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway
51/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: In addition, the overexpression of interleukin-1 (IL-1) has been implicated in tangle formation in AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-03-01
Impact of comorbidity on lung cancer survival
52/100 ✓ Peer-reviewed Brain tissue and pathology International journal of cancer
Key finding: We evaluated the impact of comorbidity on lung cancer survival. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-03-01
White matter structural integrity in healthy aging adults and patients with Alzheimer disease: a magnetic resonance imaging study
57/100 ✓ Peer-reviewed Brain tissue and pathology Archives of neurology
Key finding: Imaging and postmortem studies suggest that frontal lobe white matter (FLWM) volume expands until about the age of 44.6 years and then declines. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-03-01
Mortality and cancer incidence among individuals with Down syndrome
52/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Archives of internal medicine
Key finding: Individuals with DS have a substantially increased risk of mortality due to specific causes and may have an elevated risk of other incident cancers in addition to leukemia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-03-01
Prevalence of PD and other types of parkinsonism in three elderly populations of central Spain
49/100 ✓ Peer-reviewed Disparities Movement disorders : official journal of the Movement Disorder Society
Key finding: We found 118 subjects with parkinsonism: 81 affected by PD (68.6%), 26 drug-induced parkinsonism (22.0%), 6 parkinsonism in dementia (5.1%), 3 vascular parkinsonism (2.5%), and 2 unspecified parkinsonism (1.7%). +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-03-01
Associations of stressors and uplifts of caregiving with caregiver burden and depressive mood: a meta-analysis
63/100 ✓ Peer-reviewed Caregiving The journals of gerontology. Series B, Psychological sciences and social sciences
Key finding: Furthermore, we found evidence that the association of caregiver burden with the number of caregiving tasks, perceived uplifts of caregiving, and the level of physical impairment of the care receiver were stronger in probability samples than in convenience samples.
Full summary, score breakdown and related studies → Original source
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2003-03-01
Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study
68/100 ✓ Peer-reviewed Caregiving Archives of neurology
Key finding: More than three quarters of this representative PD cohort developed dementia during the 8-year study period. +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-03-01
Prospective study of alcohol consumption and risk of dementia in older adults
71/100 ✓ Peer-reviewed Brain scans and imaging JAMA
Key finding: Compared with abstention, consumption of 1 to 6 drinks weekly is associated with a lower risk of incident dementia among older adults. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-03-01
Dementia diagnosis in developing countries: a cross-cultural validation study
60/100 ✓ Peer-reviewed Getting a diagnosis Lancet (London, England)
Key finding: Each measure independently predicted a diagnosis of dementia.
Full summary, score breakdown and related studies → Original source
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2003-03-01
Usefulness of plasma haloperidol levels for monitoring clinical efficacy and side effects in Alzheimer patients with psychosis and behavioral dyscontrol
51/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Measurement of HL plasma levels may have potential usefulness as an adjunct in monitoring treatment response to oral HL in AD patients with psychosis or disruptive behavior. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-03-01
A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease
39/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: High-dose vitamin supplementation reduces homocysteine levels in patients with AD. +1 more finding
Full summary, score breakdown and related studies → Original source
February 2003 1
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2003-02-27
Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?
36/100 ✓ Peer-reviewed Vascular contributions Stroke
Key finding: Proof that blood-brain barrier failure is key to these conditions could provide a target for new treatments to reduce the effects of vascular disease on the brain and prevent cognitive decline and dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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