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TDP-43 pathology, cognitive decline, and dementia in old age
Wilson RS, Yu L, Trojanowski JQ, Chen EY, Boyle PA, Bennett DA, Schneider JA.. JAMA neurology, 2013-11-01
Topic: Risk, prevention and care in population studies
Importance Cognitive decline is a leading cause of disability and death in old age but its neurobiological bases are not well understood. Objective To test the hypothesis that transactive response DNA-binding protein 43 (TDP-43) is related to late-life cognitive decline. Design, setting, and participants Longitudinal clinical-pathologic cohort study involving more than 40 Catholic groups across the United States.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Wilson, R. S., Yu, L., Trojanowski, J. Q., Chen, E. Y., Boyle, P. A., Bennett, D. A., et al. (2013). TDP-43 pathology, cognitive decline, and dementia in old age. JAMA neurology. https://doi.org/10.1001/jamaneurol.2013.3961
Vancouver
Wilson RS, Yu L, Trojanowski JQ, Chen EY, Boyle PA, Bennett DA, et al. TDP-43 pathology, cognitive decline, and dementia in old age. JAMA neurology. 2013. doi:10.1001/jamaneurol.2013.3961. PMID: 24080705.
BibTeX
@article{wilson2013-24080705,
author = {Wilson, R. S. and Yu, L. and Trojanowski, J. Q. and Chen, E. Y. and Boyle, P. A. and Bennett, D. A. and Schneider, J. A.},
title = {{TDP-43 pathology, cognitive decline, and dementia in old age}},
journal = {JAMA neurology},
year = {2013},
doi = {10.1001/jamaneurol.2013.3961},
pmid = {24080705},
url = {https://doi.org/10.1001/jamaneurol.2013.3961}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Objective To test the hypothesis that transactive response DNA-binding protein 43 (TDP-43) is related to late-life cognitive decline.
- Design, setting, and participants Longitudinal clinical-pathologic cohort study involving more than 40 Catholic groups across the United States.
- A total of 130 older Catholic nuns, priests, and monks underwent annual clinical evaluations, including detailed cognitive testing, for a mean of 10.1 years prior to death.
- On neuropathologic examination, we collected semiquantitative measures of TDP-43 pathology, density of neuronal neurofibrillary tangles, area occupied by amyloid-beta plaques, and the presence of alpha-synuclein Lewy bodies from multiple brain regions.
Why it matters
This cohort study tested whether TDP-43 pathology is related to late-life cognitive decline in older Catholic clergy. It is an observational study of brain tissue and cognition and does not test any treatment or prevention.
Study details
- Study designcohort study
- Participants130
- Evidence strengthModerate
How this study scored 64/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on impact for its field and year, so that was left out: it earned 60 of the 94 points we could judge it on, which is 64 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA neurology) |
| Journal's citation record | 2 / 4 | JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 130 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 251 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 16.7 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 3 / 6 | Cited by 24 other studies in this library |
| Still being cited | 3 / 4 | Cited 59 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Julie A. Schneider: h-index 151 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Pennsylvania: institution h-index 1,859 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24080705) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 60 / 94 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 60 of the 94 points we could judge it on is 64 out of 100. |
| Total | 64 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1001/jamaneurol.2013.3961
- PubMed: 24080705
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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