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Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808
David T. Chien, Anna Katrin Szardenings, Shadfar Bahri, Joseph C. Walsh, Fanrong Mu, Chunfang A. Xia, William Rodman Shankle, Alan Jay Lerner, Min‐Ying Su, Arkadij M. Elizarov, Hartmuth Christian Kolb. Journal of Alzheimer s Disease, 2013-10-29
Topic: Brain proteins, microglia and lab models
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have recently reported early clinical results of a novel PHF-tau targeting PET imaging agent, [F18]-T807. Since then, we have investigated a second novel PHF-tau targeting PET imaging agent, [F18]-T808, with different pharmacokinetic characteristics, which may be favorable for imaging Alzheimer's disease and other tauopathies. Here, we describe the first human brain images with [F18]-T808.
Why it matters
Describes the first human brain images with [F18]-T808, a new PET imaging agent that targets tau aggregates such as neurofibrillary tangles, which are linked to the degree of cognitive impairment in Alzheimer's disease.
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How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 46 of the 95 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer s Disease) |
| Journal's citation record | 2 / 4 | Journal of Alzheimer s Disease: journal h-index 218 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 677 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 45.1 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 6 / 6 | Cited 54.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 38 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Hartmuth Christian Kolb: h-index 65 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of California, Irvine: institution h-index 1,195 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Points | 46 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 46 of the 95 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3233/jad-130098
- Original source →
- Free full text: eScholarship (California Digital Library) →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 11 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Chien, D. T., Szardenings, A. K., Bahri, S., Walsh, J. C., Mu, F., Xia, C. A., et al. (2013). Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808. Journal of Alzheimer s Disease. https://doi.org/10.3233/jad-130098
Vancouver
Chien DT, Szardenings AK, Bahri S, Walsh JC, Mu F, Xia CA, et al. Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808. Journal of Alzheimer s Disease. 2013. doi:10.3233/jad-130098.
BibTeX
@article{chien2013-ac703d18,
author = {Chien, David T. and Szardenings, Anna Katrin and Bahri, Shadfar and Walsh, Joseph C. and Mu, Fanrong and Xia, Chunfang A. and Shankle, William Rodman and Lerner, Alan Jay and Su, Min‐Ying and Elizarov, Arkadij M. and Kolb, Hartmuth Christian},
title = {{Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808}},
journal = {Journal of Alzheimer s Disease},
year = {2013},
doi = {10.3233/jad-130098},
url = {https://doi.org/10.3233/jad-130098}
}
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