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DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline
Trudler D, Weinreb O, Mandel SA, Youdim MB, Frenkel D.. Journal of neurochemistry, 2014-01-06
Topic: Brain proteins, microglia and lab models
DJ-1 is an oxidative stress sensor that localizes to the mitochondria when the cell is exposed to oxidative stress. DJ-1 mutations that result in gene deficiency are linked to increased risk of Parkinson's disease (PD). Activation of microglial stress conditions that are linked to PD may result in neuronal death.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Trudler, D., Weinreb, O., Mandel, S. A., Youdim, M. B., & Frenkel, D. (2014). DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline. Journal of neurochemistry. https://doi.org/10.1111/jnc.12633
Vancouver
Trudler D, Weinreb O, Mandel SA, Youdim MB, Frenkel D. DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline. Journal of neurochemistry. 2014. doi:10.1111/jnc.12633. PMID: 24355073.
BibTeX
@article{trudler2014-24355073,
author = {Trudler, D. and Weinreb, O. and Mandel, S. A. and Youdim, M. B. and Frenkel, D.},
title = {{DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline}},
journal = {Journal of neurochemistry},
year = {2014},
doi = {10.1111/jnc.12633},
pmid = {24355073},
url = {https://doi.org/10.1111/jnc.12633}
}
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Key findings
- DJ-1 mutations that result in gene deficiency are linked to increased risk of Parkinson's disease (PD).
- Activation of microglial stress conditions that are linked to PD may result in neuronal death.
- We postulated that DJ-1 deficiency may increase microglial neurotoxicity.
- We found that down-regulation of DJ-1 in microglia using an shRNA approach increased cell sensitivity to dopamine as measured by secreted pro-inflammatory cytokines such as IL-1β and IL-6.
Why it matters
In cell experiments, reducing DJ-1 in microglia made them more sensitive to dopamine and more likely to release inflammatory cytokines, an effect reduced by rasagiline. This is laboratory work related to Parkinson's disease, not Alzheimer's, and does not establish a treatment for patients.
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Study details
- Evidence strengthLow
How this study scored 42/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neurochemistry) |
| Journal's citation record | 3 / 4 | Journal of Neurochemistry: journal h-index 349 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 108 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.7 citations a year over 14 year(s) since 2014 |
| Impact for its field and year | 3 / 6 | Cited 4.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 2 / 4 | Cited 24 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Dan Frenkel: h-index 44 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Tel Aviv University: institution h-index 1,018 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24355073) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 42 / 100 | — |
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