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Increased cerebrospinal fluid tau levels in logopenic variant of Alzheimer's disease
Eloi Magnin, Claire Paquet, Maité Formaglio, Bernard Croisile, Ludivine Chamard, Carole Miguet-Alfonsi, Gregory Tio, Julien Dumurgier et al.. Journal of Alzheimer's disease : JAD, 2014
Topic: Plasma and spinal-fluid biomarkers
p-Tau181 levels were higher in the lvPPA-AD group than in the aMCI-AD group (p < 0.05). Total tau levels were higher in the lvPPA-AD group versus those in the nlAD (p < 0.05) and aMCI-AD (p < 0.001) groups. These results suggest a more pronounced involvement of a taupathy in lvPPA-AD compared to aMCI-AD and a more important neuronal death in lvPPA-AD than in nlAD or aMCI-AD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Magnin, E., Paquet, C., Formaglio, M., Croisile, B., Chamard, L., Miguet-Alfonsi, C., et al. (2014). Increased cerebrospinal fluid tau levels in logopenic variant of Alzheimer's disease. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-131382
Vancouver
Magnin E, Paquet C, Formaglio M, Croisile B, Chamard L, Miguet-Alfonsi C, et al. Increased cerebrospinal fluid tau levels in logopenic variant of Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2014. doi:10.3233/jad-131382. PMID: 24217280.
BibTeX
@article{magnin2014-24217280,
author = {Magnin, Eloi and Paquet, Claire and Formaglio, Maité and Croisile, Bernard and Chamard, Ludivine and Miguet-Alfonsi, Carole and Tio, Gregory and Dumurgier, Julien and others},
title = {{Increased cerebrospinal fluid tau levels in logopenic variant of Alzheimer's disease}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2014},
doi = {10.3233/jad-131382},
pmid = {24217280},
url = {https://doi.org/10.3233/jad-131382}
}
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Key findings
- p-Tau181 levels were higher in the lvPPA-AD group than in the aMCI-AD group (p < 0.05).
- Total tau levels were higher in the lvPPA-AD group versus those in the nlAD (p < 0.05) and aMCI-AD (p < 0.001) groups.
- These results suggest a more pronounced involvement of a taupathy in lvPPA-AD compared to aMCI-AD and a more important neuronal death in lvPPA-AD than in nlAD or aMCI-AD.
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Study details
- Participants30
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 25 of the 56 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 30 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24217280) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 25 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 25 of the 56 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
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