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Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation
Roberts RO, Knopman DS, Cha RH, Mielke MM, Pankratz VS, Boeve BF, Kantarci K, Geda YE et al.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014-03-20
Topic: Brain proteins, microglia and lab models
Unlabelled Dysfunctional insulin signaling may affect brain metabolism or amyloid deposition. We investigated the associations of type 2 diabetes with amyloid accumulation measured using (11)C-Pittsburgh compound B ((11)C-PiB) and brain hypometabolism measured using (18)F-FDG PET. Methods We studied a sample of nondemented participants from the population-based Mayo Clinic Study of Aging. All subjects underwent MR imaging, amyloid PET, and (18)F-FDG PET. Alzheimer disease (AD) signature and region-of-interest (ROI) measures for (11)C-PiB retention ratio and (18)F-FDG ratio were measured. Diabetes was assessed from the Rochester Epidemiology Project medical records linkage system. Results Among 749 participants (median age, 79.0 y; 56.5% men, 81.0% cognitively normal; 20.6% diabetic individuals), (18)F-FDG hypometabolism ((18)F-FDG ratio Conclusion Diabetes and poor glycemic control in nondiabetic individuals may enhance glucose hypometabolism in AD signature regions. These factors should be investigated in longitudinal studies for their role in detecting onset of symptoms in AD.
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APA 7th
Roberts, R. O., Knopman, D. S., Cha, R. H., Mielke, M. M., Pankratz, V. S., Boeve, B. F., et al. (2014). Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. https://doi.org/10.2967/jnumed.113.132647
Vancouver
Roberts RO, Knopman DS, Cha RH, Mielke MM, Pankratz VS, Boeve BF, et al. Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2014. doi:10.2967/jnumed.113.132647. PMID: 24652830.
BibTeX
@article{roberts2014-24652830,
author = {Roberts, R. O. and Knopman, D. S. and Cha, R. H. and Mielke, M. M. and Pankratz, V. S. and Boeve, B. F. and Kantarci, K. and Geda, Y. E. and others},
title = {{Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation}},
journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
year = {2014},
doi = {10.2967/jnumed.113.132647},
pmid = {24652830},
url = {https://doi.org/10.2967/jnumed.113.132647}
}
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Key findings
- Results Among 749 participants (median age, 79.0 y; 56.5% men, 81.0% cognitively normal; 20.6% diabetic individuals), (18)F-FDG hypometabolism ((18)F-FDG ratio Conclusion Diabetes and poor glycemic control in nondiabetic individuals may enhance glucose hypometabolism in AD signature regions.
Why it matters
Among 749 nondemented participants, diabetes and poor glycemic control were associated with brain hypometabolism in Alzheimer signature regions but not with amyloid accumulation. The authors say these factors should be investigated in longitudinal studies, and no treatment, cure or prevention is reported.
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Study details
- Study designlongitudinal study
- Participants749
- Effect size56.5%; 81.0%; 20.6%
- Evidence strengthModerate
How this study scored 63/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of nuclear medicine : official publication, Society of Nuclear Medicine) |
| Journal's citation record | 2 / 4 | Journal of Nuclear Medicine: journal h-index 230 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 749 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 161 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 11.5 citations a year over 14 year(s) since 2014 |
| Impact for its field and year | 4 / 6 | Cited 11.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 17 other studies in this library |
| Still being cited | 2 / 4 | Cited 27 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Val J. Lowe: h-index 107 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Mayo Clinic: institution h-index 1,606 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24652830) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 63 / 100 | — |
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