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A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease
Frank Jessen, Rebecca England Amariglio, Martin P.J. van Boxtel, Monique M.B. Breteler, Mathieu Ceccaldi, Gaël Chételat, Bruno Dubois, Carole Dufouil et al.. Alzheimer s & Dementia, 2014-05-02
Topic: Risk, prevention and care in population studies
There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD plus.
Key findings
- The research on SCD in early AD, however, is limited by the absence of common standards.
- The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD.
- In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented.
- In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings.
- Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD.
Why it matters
This paper presents a conceptual framework and research criteria for studying subjective cognitive decline in preclinical Alzheimer's disease. It is a framework paper and does not directly address treating, curing, or preventing Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 60/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 58 of the 96 points we could judge it on, which is 60 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 3,017 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 215.5 citations a year over 14 year(s) since 2014 |
| Impact for its field and year | 6 / 6 | Cited 68.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 5 / 6 | Cited by 121 other studies in this library |
| Still being cited | 4 / 4 | Cited 1,067 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 31 institution(s) in 7 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24798886) |
| Free to read | 2 / 2 | Free to read |
| Points | 58 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 58 of the 96 points we could judge it on is 60 out of 100. |
| Total | 60 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.jalz.2014.01.001
- PubMed: 24798886
- Original source →
- Free full text: Alzheimer s & Dementia →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Jessen, F., Amariglio, R. E., van Boxtel, M. P., Breteler, M. M., Ceccaldi, M., Chételat, G., et al. (2014). A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimer s & Dementia. https://doi.org/10.1016/j.jalz.2014.01.001
Vancouver
Jessen F, Amariglio RE, van Boxtel MP, Breteler MM, Ceccaldi M, Chételat G, et al. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimer s & Dementia. 2014. doi:10.1016/j.jalz.2014.01.001. PMID: 24798886.
BibTeX
@article{jessen2014-24798886,
author = {Jessen, Frank and Amariglio, Rebecca England and van Boxtel, Martin P.J. and Breteler, Monique M.B. and Ceccaldi, Mathieu and Chételat, Gaël and Dubois, Bruno and Dufouil, Carole and others},
title = {{A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease}},
journal = {Alzheimer s \& Dementia},
year = {2014},
doi = {10.1016/j.jalz.2014.01.001},
pmid = {24798886},
url = {https://doi.org/10.1016/j.jalz.2014.01.001}
}
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