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Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis
Menke RA, Körner S, Filippini N, Douaud G, Knight S, Talbot K, Turner MR.. Brain : a journal of neurology, 2014-06-20
Topic: Brain proteins, microglia and lab models
Longitudinal analysis revealed progressive and widespread changes in the grey matter, notably including the basal ganglia. Such changes were significant across a range of apparently sporadic patients rather than being a genotype-specific effect. It is also suggested that the upper motor neuron lesion in amyotrophic lateral sclerosis may be relatively constant during the established symptomatic period. These findings have implications for the development of effective diagnostic versus therapeutic monitoring magnetic resonance imaging biomarkers.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Menke, R. A., Körner, S., Filippini, N., Douaud, G., Knight, S., Talbot, K., et al. (2014). Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis. Brain : a journal of neurology. https://doi.org/10.1093/brain/awu162
Vancouver
Menke RA, Körner S, Filippini N, Douaud G, Knight S, Talbot K, et al. Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis. Brain : a journal of neurology. 2014. doi:10.1093/brain/awu162. PMID: 24951638.
BibTeX
@article{menke2014-24951638,
author = {Menke, R. A. and Körner, S. and Filippini, N. and Douaud, G. and Knight, S. and Talbot, K. and Turner, M. R.},
title = {{Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis}},
journal = {Brain : a journal of neurology},
year = {2014},
doi = {10.1093/brain/awu162},
pmid = {24951638},
url = {https://doi.org/10.1093/brain/awu162}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Longitudinal analysis revealed progressive and widespread changes in the grey matter, notably including the basal ganglia.
- Such changes were significant across a range of apparently sporadic patients rather than being a genotype-specific effect.
- It is also suggested that the upper motor neuron lesion in amyotrophic lateral sclerosis may be relatively constant during the established symptomatic period.
- These findings have implications for the development of effective diagnostic versus therapeutic monitoring magnetic resonance imaging biomarkers.
Why it matters
Longitudinal MRI in amyotrophic lateral sclerosis showed progressive and widespread grey matter changes, including the basal ganglia, across apparently sporadic patients rather than being genotype-specific. This concerns amyotrophic lateral sclerosis and has implications for MRI biomarkers, not for treating, curing, or preventing Alzheimer's disease.
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Study details
- Study designcross-sectional
- Participants36
- Evidence strengthModerate
How this study scored 59/100
Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain : a journal of neurology) |
| Journal's citation record | 4 / 4 | Brain: journal h-index 503 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 36 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 189 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 13.5 citations a year over 14 year(s) since 2014 |
| Impact for its field and year | 4 / 6 | Cited 12.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 34 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Martin R. Turner: h-index 84 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Oxford: institution h-index 2,205 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24951638) |
| Free to read | 2 / 2 | Free to read |
| Total | 59 / 100 | — |
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Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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