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Histone deacetylases (HDACs) in frontotemporal lobar degeneration
Amy Whitehouse, Klara Doherty, Hsin Hsien Yeh, Andrew C. Robinson, Sara Rollinson, Stuart Pickering‐Brown, Julie Snowden, Jennifer C Thompson et al.. Neuropathology and Applied Neurobiology, 2015-01-29
Topic: Disease mechanisms in lab and animal studies
We found a significantly greater intensity of cytoplasmic immunostaining for HDAC4 and HDAC6 in granule cells of the dentate gyrus in cases of FTLD overall compared with controls, and specifically in cases of FTLD tau‐ P icks compared with FTLD tau‐ MAPT and controls. No differences were noted between FTLD ‐ TDP subtypes, or between the different genetic and nongenetic forms of FTLD . No changes were seen in HDAC5 in any FTLD or control cases. Dysregulation of HDAC4 and/or HDAC6 could play a role in the pathogenesis of FTLD ‐tau associated with Pick bodies, although their lack of immunostaining implies that such changes do not contribute directly to the formation of P ick bodies.
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APA 7th
Whitehouse, A., Doherty, K., Yeh, H. H., Robinson, A. C., Rollinson, S., Pickering‐Brown, S., et al. (2015). Histone deacetylases (HDACs) in frontotemporal lobar degeneration. Neuropathology and Applied Neurobiology. https://doi.org/10.1111/nan.12153
Vancouver
Whitehouse A, Doherty K, Yeh HH, Robinson AC, Rollinson S, Pickering‐Brown S, et al. Histone deacetylases (HDACs) in frontotemporal lobar degeneration. Neuropathology and Applied Neurobiology. 2015. doi:10.1111/nan.12153.
BibTeX
@article{whitehouse2015-2cd2e5f3,
author = {Whitehouse, Amy and Doherty, Klara and Yeh, Hsin Hsien and Robinson, Andrew C. and Rollinson, Sara and Pickering‐Brown, Stuart and Snowden, Julie and Thompson, Jennifer C and others},
title = {{Histone deacetylases (HDACs) in frontotemporal lobar degeneration}},
journal = {Neuropathology and Applied Neurobiology},
year = {2015},
doi = {10.1111/nan.12153},
url = {https://doi.org/10.1111/nan.12153}
}
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Key findings
- We found a significantly greater intensity of cytoplasmic immunostaining for HDAC4 and HDAC6 in granule cells of the dentate gyrus in cases of FTLD overall compared with controls, and specifically in cases of FTLD tau‐ P icks compared with FTLD tau‐ MAPT and controls.
- No differences were noted between FTLD ‐ TDP subtypes, or between the different genetic and nongenetic forms of FTLD .
- No changes were seen in HDAC5 in any FTLD or control cases.
- Dysregulation of HDAC4 and/or HDAC6 could play a role in the pathogenesis of FTLD ‐tau associated with Pick bodies, although their lack of immunostaining implies that such changes do not contribute directly to the formation of P ick bodies.
Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 20 of the 56 points we could judge it on, which is 36 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neuropathology and Applied Neurobiology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 20 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 20 of the 56 points we could judge it on is 36 out of 100. |
| Total | 36 / 100 | — |
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