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43/100

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Brain scans and imaging

Topic: Amyloid, tau and blood-test diagnosis

Introduction The accumulation of neurofibrillary tangles, composed of aggregated hyperphosphorylated tau protein, starts spreading early in specific regions in the course of Alzheimer's disease (AD), correlating with the progression of memory dysfunction. The non-invasive imaging of tau could therefore facilitate the early diagnosis of AD, differentiate it from other dementing disorders and allow evaluation of tau immunization therapy outcomes. In this study we characterized the in vitro binding properties of THK5117, a tentative radiotracer for positron emission tomography (PET) imaging of tau brain deposits. Results Saturation and competition binding studies of (3)H-THK5117 in post-mortem AD brain tissue showed the presence of multiple binding sites. THK5117 binding was significantly higher in hippocampal (p Conclusions This study supports that new tau PET tracers will provide further understanding on the role of tau pathology in the diversity of the clinical presentation in AD.

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APA 7th

Lemoine, L., Saint-Aubert, L., Marutle, A., Antoni, G., Eriksson, J. P., Ghetti, B., et al. (2015). Visualization of regional tau deposits using (3)H-THK5117 in Alzheimer brain tissue. Acta neuropathologica communications. https://doi.org/10.1186/s40478-015-0220-4

Vancouver

Lemoine L, Saint-Aubert L, Marutle A, Antoni G, Eriksson JP, Ghetti B, et al. Visualization of regional tau deposits using (3)H-THK5117 in Alzheimer brain tissue. Acta neuropathologica communications. 2015. doi:10.1186/s40478-015-0220-4. PMID: 26134112.

BibTeX

@article{lemoine2015-26134112,
  author  = {Lemoine, L. and Saint-Aubert, L. and Marutle, A. and Antoni, G. and Eriksson, J. P. and Ghetti, B. and Okamura, N. and Nennesmo, I. and others},
  title   = {{Visualization of regional tau deposits using (3)H-THK5117 in Alzheimer brain tissue}},
  journal = {Acta neuropathologica communications},
  year    = {2015},
  doi     = {10.1186/s40478-015-0220-4},
  pmid    = {26134112},
  url     = {https://doi.org/10.1186/s40478-015-0220-4}
}

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Key findings

Results Saturation and competition binding studies of (3)H-THK5117 in post-mortem AD brain tissue showed the presence of multiple binding sites.
THK5117 binding was significantly higher in hippocampal (p Conclusions This study supports that new tau PET tracers will provide further understanding on the role of tau pathology in the diversity of the clinical presentation in AD.

Why it matters

This laboratory study characterized how the tracer THK5117 binds to tau deposits in post-mortem Alzheimer brain tissue. It is early in-vitro work to support future tau PET imaging, not a treatment, cure or prevention.

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Study details

Evidence strengthLow

How this study scored 43/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Acta neuropathologica communications)
Journal's citation record	1 / 4	Acta Neuropathologica Communications: journal h-index 129 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2015 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 65 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	5.0 citations a year over 13 year(s) since 2015
Impact for its field and year	3 / 6	Cited 6.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 9 other studies in this library
Still being cited	1 / 4	Cited 7 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Agneta K. Nordberg: h-index 103 (OpenAlex, whole career)
Institution's track record	1 / 3	Karolinska Institutet: institution h-index 1,477 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 7 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 26134112)
Free to read	2 / 2	Free to read
Total	43 / 100	—

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