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63/100

✓ Peer-reviewed alzhub usefulness score 63 out of 100. Genetics

Topic: Amyloid, tau and blood-test diagnosis

Plain-language summary

Objective To investigate in vivo the relationship of regional brain β-amyloid (Aβ) to gait speed in a group of elderly individuals at high risk for dementia. Methods Cross-sectional associations between brain Aβ as measured with [18F]florbetapir PET and gait speed were examined in 128 elderly participants. Subjects ranged from healthy to mildly cognitively impaired enrolled in the control arm of the multidomain intervention in the Multidomain Alzheimer Preventive Trial (MAPT). Nearly all participants presented spontaneous memory complaints. Regional [18F]florbetapir (AV45) standardized uptake volume ratios were obtained via semiautomated quantitative analysis using the cerebellum as reference region. Gait speed was measured by timing participants while they walked 4 meters. Associations were explored with linear regression, correcting for age, sex, education, body mass index (BMI), and APOE genotype. Results We found a significant association between Aβ in the posterior and anterior putamen, occipital cortex, precuneus, and anterior cingulate and slow gait speed (all corrected p Conclusions The present PET study confirms, in vivo, previous postmortem evidence showing an association between Alzheimer disease (AD) pathology and gait speed, and provides additional evidence on potential regional effects of brain Aβ on motor function. More research is needed to elucidate the neural mechanisms underlying these regional associations, which may involve motor and sensorimotor circuits hitherto largely neglected in the pathophysiology of AD.

What this study adds

Evidence grade: Low

This is a cross-sectional study. The authors say this confirms in living people earlier postmortem evidence linking Alzheimer's pathology to gait speed. Because everyone was measured once, it shows a link, not that amyloid causes slower walking; the mechanisms remain unknown.

Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Del Campo, N., Payoux, P., Djilali, A., Delrieu, J., Hoogendijk, E. O., Rolland, Y., et al. (2016). Relationship of regional brain β-amyloid to gait speed. Neurology. https://doi.org/10.1212/wnl.0000000000002235

Vancouver

Del Campo N, Payoux P, Djilali A, Delrieu J, Hoogendijk EO, Rolland Y, et al. Relationship of regional brain β-amyloid to gait speed. Neurology. 2016. doi:10.1212/wnl.0000000000002235. PMID: 26643548.

BibTeX

@article{delcampo2016-26643548,
  author  = {Del Campo, N. and Payoux, P. and Djilali, A. and Delrieu, J. and Hoogendijk, E. O. and Rolland, Y. and Cesari, M. and Weiner, M. W. and others},
  title   = {{Relationship of regional brain β-amyloid to gait speed}},
  journal = {Neurology},
  year    = {2016},
  doi     = {10.1212/wnl.0000000000002235},
  pmid    = {26643548},
  url     = {https://doi.org/10.1212/wnl.0000000000002235}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

How to read this study

Design: this is a cross-sectional study. Everyone is measured once, so it cannot show which came first. Read it as a snapshot of how two things go together at one moment.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

Results We found a significant association between Aβ in the posterior and anterior putamen, occipital cortex, precuneus, and anterior cingulate and slow gait speed (all corrected p < 0.05).

Why it matters

In 128 older adults at high risk for dementia, nearly all with memory complaints, those with more amyloid on PET scans in the putamen, occipital cortex, precuneus and anterior cingulate walked more slowly over 4 meters, after adjusting for age, sex, education, BMI and APOE genotype. The authors say this confirms in living people earlier postmortem evidence linking Alzheimer's pathology to gait speed. Because everyone was measured once, it shows a link, not that amyloid causes slower walking; the mechanisms remain unknown.

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Study details

Study designcross-sectional
Evidence strengthLow

How this study scored 63/100

Published in a leading specialty journal, and it is a large phase 3 trial. Scored zero for sample size, effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Neurology)
Journal's citation record	4 / 4	Neurology: journal h-index 525 (OpenAlex, 2026-10-29)
Study design	11 / 12	A large phase 3 trial (from PubMed type “Clinical Trial, Phase III”)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2016 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (pubmed indexes it as a clinical or observational study)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 147 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	12.2 citations a year over 12 year(s) since 2016
Impact for its field and year	4 / 6	Cited 11.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 9 other studies in this library
Still being cited	2 / 4	Cited 30 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Julien Delrieu: h-index 31 (OpenAlex, whole career)
Institution's track record	2 / 3	Inserm: institution h-index 1,988 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 8 institution(s) in 4 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 26643548)
Free to read	0 / 2	Behind a paywall — scores zero
Total	63 / 100	—

What each of these 20 components measures, and what this score is not →

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