Dura mater is a potential source of Aβ seeds
Kovacs GG, Lutz MI, Ricken G, Ströbel T, Höftberger R, Preusser M, Regelsberger G, Hönigschnabl S et al.. Acta neuropathologica, 2016-03-25
Topic: Brain proteins, microglia and lab models
Deposition of amyloid-β (Aβ) in the brain parenchyma and vessels is one of the hallmarks of Alzheimer disease (AD). Recent observations of Aβ deposition in iatrogenic Creutzfeldt-Jakob disease (iCJD) after dural grafting or treatment with pituitary extracts raised concerns whether Aβ is capable of transmitting disease as seen in prion diseases by the disease-associated prion protein. To address this issue, we re-sampled and re-evaluated archival material, including the grafted dura mater of two cases with iCJD (28 and 33-years-old) without mutations in the AβPP, PSEN1 and PSEN2 genes, and carrying ε3/ε3 alleles of the APOE gene. In addition, we evaluated 84 dura mater samples obtained at autopsy (mean age 84.9 ± 0.3) in the community-based VITA study for the presence of Aβ deposition. We show that the dura mater may harbor Aβ deposits (13 %) in the form of cerebral amyloid angiopathy or amorphous aggregates. In both iCJD cases, the grafted dura mater had accumulated Aβ. The morphology and distribution pattern of cerebral Aβ deposition together with the lack of tau pathology distinguishes the Aβ proteinopathy in iCJD from AD, from that seen in young individuals without cognitive decline carrying one or two APOE4 alleles, and from that related to traumatic brain injury. Our novel findings of Aβ deposits in the dura mater, including the grafted dura, and the distinct cerebral Aβ distribution in iCJD support the seeding properties of Aβ. However, in contrast to prion diseases, our study suggests that such Aβ seeding is unable to reproduce the full clinicopathological phenotype of AD.
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APA 7th
Kovacs, G. G., Lutz, M. I., Ricken, G., Ströbel, T., Höftberger, R., Preusser, M., et al. (2016). Dura mater is a potential source of Aβ seeds. Acta neuropathologica. https://doi.org/10.1007/s00401-016-1565-x
Vancouver
Kovacs GG, Lutz MI, Ricken G, Ströbel T, Höftberger R, Preusser M, et al. Dura mater is a potential source of Aβ seeds. Acta neuropathologica. 2016. doi:10.1007/s00401-016-1565-x. PMID: 27016065.
BibTeX
@article{kovacs2016-27016065,
author = {Kovacs, G. G. and Lutz, M. I. and Ricken, G. and Ströbel, T. and Höftberger, R. and Preusser, M. and Regelsberger, G. and Hönigschnabl, S. and others},
title = {{Dura mater is a potential source of Aβ seeds}},
journal = {Acta neuropathologica},
year = {2016},
doi = {10.1007/s00401-016-1565-x},
pmid = {27016065},
url = {https://doi.org/10.1007/s00401-016-1565-x}
}
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Key findings
- However, in contrast to prion diseases, our study suggests that such Aβ seeding is unable to reproduce the full clinicopathological phenotype of AD.
Why it matters
This study found that the dura mater can harbor amyloid-beta deposits, including in grafted dura mater from two cases. However, it suggests this seeding is unable to reproduce the full clinical and pathological picture of Alzheimer disease.
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Study details
- Evidence strengthLow
How this study scored 52/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Acta neuropathologica) |
| Journal's citation record | 3 / 4 | Acta Neuropathologica: journal h-index 287 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 109 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 9.1 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 4 / 6 | Cited 12.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 19 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Johannes Andreas Hainfellner: h-index 65 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Medical University of Vienna: institution h-index 818 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27016065) |
| Free to read | 2 / 2 | Free to read |
| Total | 52 / 100 | — |
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Read the original
- DOI: 10.1007/s00401-016-1565-x
- PubMed: 27016065
- Original source →
- Free full text: Acta Neuropathologica →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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