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Lower cerebral blood flow is associated with faster cognitive decline in Alzheimer's disease
Benedictus MR, Leeuwis AE, Binnewijzend MA, Kuijer JP, Scheltens P, Barkhof F, van der Flier WM, Prins ND.. European radiology, 2016-06-22
Topic: Amyloid, tau and blood-test diagnosis
Objective To determine whether lower cerebral blood flow (CBF) is associated with faster cognitive decline in patients with Alzheimer's disease (AD). Methods We included 88 patients with dementia due to AD from the Amsterdam Dementia Cohort. Linear mixed models were used to determine associations of lower whole brain and regional pseudo-continuous arterial spin labelling measured CBF with rate of cognitive decline as measured with repeated mini-mental state examination (MMSE).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Benedictus, M. R., Leeuwis, A. E., Binnewijzend, M. A., Kuijer, J. P., Scheltens, P., Barkhof, F., et al. (2017). Lower cerebral blood flow is associated with faster cognitive decline in Alzheimer's disease. European radiology. https://doi.org/10.1007/s00330-016-4450-z
Vancouver
Benedictus MR, Leeuwis AE, Binnewijzend MA, Kuijer JP, Scheltens P, Barkhof F, et al. Lower cerebral blood flow is associated with faster cognitive decline in Alzheimer's disease. European radiology. 2017. doi:10.1007/s00330-016-4450-z. PMID: 27334014.
BibTeX
@article{benedictus2017-27334014,
author = {Benedictus, M. R. and Leeuwis, A. E. and Binnewijzend, M. A. and Kuijer, J. P. and Scheltens, P. and Barkhof, F. and van der Flier, W. M. and Prins, N. D.},
title = {{Lower cerebral blood flow is associated with faster cognitive decline in Alzheimer's disease}},
journal = {European radiology},
year = {2017},
doi = {10.1007/s00330-016-4450-z},
pmid = {27334014},
url = {https://doi.org/10.1007/s00330-016-4450-z}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Methods We included 88 patients with dementia due to AD from the Amsterdam Dementia Cohort.
- Linear mixed models were used to determine associations of lower whole brain and regional pseudo-continuous arterial spin labelling measured CBF with rate of cognitive decline as measured with repeated mini-mental state examination (MMSE).
- Model 1 was adjusted for age, sex, and education.
- Model 2 was additionally adjusted for normalized gray matter volume, medial temporal lobe atrophy, white matter hyperintensities, microbleeds, and lacunes.
Why it matters
In 88 patients with Alzheimer's dementia, this study examined whether lower cerebral blood flow was linked to faster cognitive decline measured by repeated MMSE scores. The provided text does not report the results, so it is unknown whether blood flow predicted the rate of decline.
Study details
- Participants88
- Evidence strengthModerate
How this study scored 52/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European radiology) |
| Journal's citation record | 2 / 4 | European Radiology: journal h-index 211 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 88 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 118 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 10.7 citations a year over 11 year(s) since 2017 |
| Impact for its field and year | 3 / 6 | Cited 7.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 2 / 4 | Cited 21 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Niels D. Prins: h-index 54 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Amsterdam UMC Location Vrije Universiteit Amsterdam: institution h-index 938 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27334014) |
| Free to read | 2 / 2 | Free to read |
| Total | 52 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1007/s00330-016-4450-z
- PubMed: 27334014
- Original source →
- Free full text: European Radiology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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