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Prestroke Vascular Pathology and the Risk of Recurrent Stroke and Poststroke Dementia
Portegies ML, Wolters FJ, Hofman A, Ikram MK, Koudstaal PJ, Ikram MA.. Stroke, 2016-07-14
Topic: Brain proteins, microglia and lab models
Plain-language summary
Background and purpose Improved short-term survival after stroke has necessitated quantifying risk and risk factors of long-term sequelae after stroke (ie, recurrent stroke and dementia). This risk may be influenced by exposure to cardiovascular risk factors before the initial stroke. Within the population-based Rotterdam Study, we determined the long-term risk of recurrent stroke and dementia, and the proportion of recurrent strokes and poststroke dementia cases that are attributable to prestroke cardiovascular risk factors (ie, the population attributable risk).
What this study adds
Evidence grade: Low
The record lists 1,237 participants. This study estimated the long-term risk of recurrent stroke and poststroke dementia and how much of that risk is attributable to cardiovascular risk factors before the first stroke. It is an observational study, so it cannot prove that controlling these risk factors prevents poststroke dementia.
Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Portegies, M. L., Wolters, F. J., Hofman, A., Ikram, M. K., Koudstaal, P. J., & Ikram, M. A. (2016). Prestroke Vascular Pathology and the Risk of Recurrent Stroke and Poststroke Dementia. Stroke. https://doi.org/10.1161/strokeaha.116.014094
Vancouver
Portegies ML, Wolters FJ, Hofman A, Ikram MK, Koudstaal PJ, Ikram MA. Prestroke Vascular Pathology and the Risk of Recurrent Stroke and Poststroke Dementia. Stroke. 2016. doi:10.1161/strokeaha.116.014094. PMID: 27418596.
BibTeX
@article{portegies2016-27418596,
author = {Portegies, M. L. and Wolters, F. J. and Hofman, A. and Ikram, M. K. and Koudstaal, P. J. and Ikram, M. A.},
title = {{Prestroke Vascular Pathology and the Risk of Recurrent Stroke and Poststroke Dementia}},
journal = {Stroke},
year = {2016},
doi = {10.1161/strokeaha.116.014094},
pmid = {27418596},
url = {https://doi.org/10.1161/strokeaha.116.014094}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- This risk may be influenced by exposure to cardiovascular risk factors before the initial stroke.
- Within the population-based Rotterdam Study, we determined the long-term risk of recurrent stroke and dementia, and the proportion of recurrent strokes and poststroke dementia cases that are attributable to prestroke cardiovascular risk factors (ie, the population attributable risk).
- Methods We followed up 1237 patients with first-ever stroke and 4928 stroke-free participants, matched on age, sex, examination round, and stroke date (index date), for the occurrence of stroke or dementia.
- We calculated incidence rates in both groups and estimated the individual and combined population attributable risk of prestroke cardiovascular risk factors for both outcomes.
Why it matters
This study estimated the long-term risk of recurrent stroke and poststroke dementia and how much of that risk is attributable to cardiovascular risk factors before the first stroke. It is an observational study, so it cannot prove that controlling these risk factors prevents poststroke dementia.
Study details
- Participants1,237
- Evidence strengthLow
How this study scored 51/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Stroke) |
| Journal's citation record | 3 / 4 | Stroke: journal h-index 455 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,237 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 66 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.5 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 3 / 6 | Cited 5.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 2 / 4 | Cited 17 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author M. Arfan Ikram: h-index 167 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27418596) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 51 / 100 | — |
What each of these 20 components measures, and what this score is not →
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