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Cognitive impairment and dementia: a new emerging complication of type 2 diabetes-The diabetologist's perspective
Simó R, Ciudin A, Simó-Servat O, Hernández C.. Acta diabetologica, 2017-02-16
Topic: Risk, prevention and care in population studies
Type 2 diabetes mellitus (T2D) and Alzheimer's disease (AD) are two of the most common diseases of aging around the world. Given the frequency with which T2D and AD occur, the notion that people with T2D may be at increased risk for AD has large societal consequences, and understanding the mechanistic links between these diseases is imperative for the development of effective AD prevention and treatment strategies. Apart from being an accelerator of AD, T2D is associated with a progressive cognitive decline. Impaired insulin signaling, inflammation, the accumulation of advanced glycation end-products and oxidative stress all play an essential role in the pathogenesis of both AD and diabetic complications. Therefore, it is reasonable to postulate that these pathways are involved in the increased risk of dementia that occurs in the T2D population. The early diagnosis of cognitive impairment and the identification of the subset of patients at a higher risk of developing AD is a challenge for healthcare providers, and meeting it will permit us to implement a personalized medicine, which is an essential issue in diabetes care with significant therapeutic implications. The main gaps that should be filled to achieve this objective are examined.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Simó, R., Ciudin, A., Simó-Servat, O., & Hernández, C. (2017). Cognitive impairment and dementia: a new emerging complication of type 2 diabetes-The diabetologist's perspective. Acta diabetologica. https://doi.org/10.1007/s00592-017-0970-5
Vancouver
Simó R, Ciudin A, Simó-Servat O, Hernández C. Cognitive impairment and dementia: a new emerging complication of type 2 diabetes-The diabetologist's perspective. Acta diabetologica. 2017. doi:10.1007/s00592-017-0970-5. PMID: 28210868.
BibTeX
@article{simo2017-28210868,
author = {Simó, R. and Ciudin, A. and Simó-Servat, O. and Hernández, C.},
title = {{Cognitive impairment and dementia: a new emerging complication of type 2 diabetes-The diabetologist's perspective}},
journal = {Acta diabetologica},
year = {2017},
doi = {10.1007/s00592-017-0970-5},
pmid = {28210868},
url = {https://doi.org/10.1007/s00592-017-0970-5}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Given the frequency with which T2D and AD occur, the notion that people with T2D may be at increased risk for AD has large societal consequences, and understanding the mechanistic links between these diseases is imperative for the development of effective AD prevention and treatment strategies.
- Apart from being an accelerator of AD, T2D is associated with a progressive cognitive decline.
- Therefore, it is reasonable to postulate that these pathways are involved in the increased risk of dementia that occurs in the T2D population.
- The early diagnosis of cognitive impairment and the identification of the subset of patients at a higher risk of developing AD is a challenge for healthcare providers, and meeting it will permit us to implement a personalized medicine, which is an essential issue in diabetes care with significant therapeutic implications.
Why it matters
This review discusses how type 2 diabetes may increase the risk of Alzheimer's disease and is associated with progressive cognitive decline, with impaired insulin signalling, inflammation, advanced glycation end-products and oxidative stress proposed as shared pathways. It is a perspective piece and does not report any tested prevention or treatment for dementia.
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Study details
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Acta diabetologica) |
| Journal's citation record | 1 / 4 | Acta Diabetologica: journal h-index 107 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 171 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 15.5 citations a year over 11 year(s) since 2017 |
| Impact for its field and year | 4 / 6 | Cited 15.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 2 / 4 | Cited 35 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Cristina Hernández: h-index 70 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Universitat Autònoma de Barcelona: institution h-index 782 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28210868) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 45 / 100 | — |
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