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Blood cholesterol in late-life and cognitive decline: a longitudinal study of the Chinese elderly
Ma C, Yin Z, Zhu P, Luo J, Shi X, Gao X.. Molecular neurodegeneration, 2017-03-07
Topic: Risk, prevention and care in population studies
Background Previous studies regarding the lipid-cognition relation in older adults are limited and have generated mixed results. We thus examined whether higher blood cholesterol concentrations were associated with faster cognitive decline in a community-based longitudinal study of Chinese elderly. Methods The study included 1,159 Chinese adults aged over 60 years (women: 48.7%, mean age: 79.4 years), who were free of dementia, Parkinson disease and stroke at the baseline.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Ma, C., Yin, Z., Zhu, P., Luo, J., Shi, X., & Gao, X. (2017). Blood cholesterol in late-life and cognitive decline: a longitudinal study of the Chinese elderly. Molecular neurodegeneration. https://doi.org/10.1186/s13024-017-0167-y
Vancouver
Ma C, Yin Z, Zhu P, Luo J, Shi X, Gao X. Blood cholesterol in late-life and cognitive decline: a longitudinal study of the Chinese elderly. Molecular neurodegeneration. 2017. doi:10.1186/s13024-017-0167-y. PMID: 28270179.
BibTeX
@article{ma2017-28270179,
author = {Ma, C. and Yin, Z. and Zhu, P. and Luo, J. and Shi, X. and Gao, X.},
title = {{Blood cholesterol in late-life and cognitive decline: a longitudinal study of the Chinese elderly}},
journal = {Molecular neurodegeneration},
year = {2017},
doi = {10.1186/s13024-017-0167-y},
pmid = {28270179},
url = {https://doi.org/10.1186/s13024-017-0167-y}
}
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Key findings
- We thus examined whether higher blood cholesterol concentrations were associated with faster cognitive decline in a community-based longitudinal study of Chinese elderly.
- Methods The study included 1,159 Chinese adults aged over 60 years (women: 48.7%, mean age: 79.4 years), who were free of dementia, Parkinson disease and stroke at the baseline.
- Blood concentrations of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), were assessed at the baseline.
- Global cognitive functions were assessed using the Chinese Mini-Mental State Examination (MMSE) at in 2009, 2012 and 2014.
Why it matters
This study followed 1,159 older Chinese adults to see whether higher blood cholesterol was linked to faster cognitive decline. It does not test any treatment, cure, or prevention for Alzheimer's disease.
Study details
- Study designlongitudinal study
- Participants90
- Effect size48.7%
- Evidence strengthModerate
How this study scored 62/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Molecular neurodegeneration) |
| Journal's citation record | 2 / 4 | Molecular Neurodegeneration: journal h-index 164 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 90 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 136 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 12.4 citations a year over 11 year(s) since 2017 |
| Impact for its field and year | 4 / 6 | Cited 8.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 39 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Xiang Gao: h-index 102 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Pennsylvania State University: institution h-index 1,397 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28270179) |
| Free to read | 2 / 2 | Free to read |
| Total | 62 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s13024-017-0167-y
- PubMed: 28270179
- Original source →
- Free full text: Molecular Neurodegeneration →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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