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Glucose Peaks and the Risk of Dementia and 20-Year Cognitive Decline
Rawlings AM, Sharrett AR, Mosley TH, Ballew SH, Deal JA, Selvin E.. Diabetes care, 2017-05-12
Topic: Risk, prevention and care in population studies
Objective Hemoglobin A 1c (HbA 1c ), a measure of average blood glucose level, is associated with the risk of dementia and cognitive impairment. However, the role of glycemic variability or glucose excursions in this association is unclear. We examined the association of glucose peaks in midlife, as determined by the measurement of 1,5-anhydroglucitol (1,5-AG) level, with the risk of dementia and 20-year cognitive decline.
Key findings
- However, the role of glycemic variability or glucose excursions in this association is unclear.
- We examined the association of glucose peaks in midlife, as determined by the measurement of 1,5-anhydroglucitol (1,5-AG) level, with the risk of dementia and 20-year cognitive decline.
- Research design and methods Nearly 13,000 participants from the Atherosclerosis Risk in Communities (ARIC) study were examined.
- Dementia was ascertained from surveillance, neuropsychological testing, telephone calls with participants or their proxies, or death certificate dementia codes.
Why it matters
This study examined whether glucose peaks in midlife, measured by 1,5-anhydroglucitol, are associated with dementia risk and 20-year cognitive decline. It reports an association with a blood measure, so it does not show that controlling glucose peaks prevents or treats Alzheimer's disease.
Study details
- Participants13,000
- Evidence strengthLow
How this study scored 60/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Diabetes care) |
| Journal's citation record | 4 / 4 | Diabetes Care: journal h-index 509 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 4 / 4 | 13,000 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 111 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 10.1 citations a year over 11 year(s) since 2017 |
| Impact for its field and year | 4 / 6 | Cited 8.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 2 / 4 | Cited 30 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Elizabeth Selvin: h-index 114 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Johns Hopkins University: institution h-index 2,306 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28500217) |
| Free to read | 2 / 2 | Free to read |
| Total | 60 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Rawlings, A. M., Sharrett, A. R., Mosley, T. H., Ballew, S. H., Deal, J. A., & Selvin, E. (2017). Glucose Peaks and the Risk of Dementia and 20-Year Cognitive Decline. Diabetes care. https://doi.org/10.2337/dc16-2203
Vancouver
Rawlings AM, Sharrett AR, Mosley TH, Ballew SH, Deal JA, Selvin E. Glucose Peaks and the Risk of Dementia and 20-Year Cognitive Decline. Diabetes care. 2017. doi:10.2337/dc16-2203. PMID: 28500217.
BibTeX
@article{rawlings2017-28500217,
author = {Rawlings, A. M. and Sharrett, A. R. and Mosley, T. H. and Ballew, S. H. and Deal, J. A. and Selvin, E.},
title = {{Glucose Peaks and the Risk of Dementia and 20-Year Cognitive Decline}},
journal = {Diabetes care},
year = {2017},
doi = {10.2337/dc16-2203},
pmid = {28500217},
url = {https://doi.org/10.2337/dc16-2203}
}
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