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Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy
Wyatt SK, Witt T, Barbaro NM, Cohen-Gadol AA, Brewster AL.. Experimental neurology, 2017-06-07
Topic: Brain proteins, microglia and lab models
Microglia-mediated neuroinflammation is widely associated with seizures and epilepsy. Although microglial cells are professional phagocytes, less is known about the status of this phenotype in epilepsy. Recent evidence supports that phagocytosis-associated molecules from the classical complement (C1q-C3) play novel roles in microglia-mediated synaptic pruning.
Key findings
- Although microglial cells are professional phagocytes, less is known about the status of this phenotype in epilepsy.
- Recent evidence supports that phagocytosis-associated molecules from the classical complement (C1q-C3) play novel roles in microglia-mediated synaptic pruning.
- Interestingly, in human and experimental epilepsy, altered mRNA levels of complement molecules were reported.
- Therefore, to identify a potential role for complement and microglia in the synaptodendritic pathology of epilepsy, we determined the protein levels of classical complement proteins (C1q-C3) along with other phagocytosis signaling molecules in human epilepsy.
Why it matters
This study examines complement molecules and microglia in human epilepsy, not Alzheimer's disease. It reports altered mRNA levels of complement molecules in epilepsy but provides no information on treating, curing or preventing Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 44/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Experimental neurology) |
| Journal's citation record | 3 / 4 | Experimental Neurology: journal h-index 271 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 104 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 9.5 citations a year over 11 year(s) since 2017 |
| Impact for its field and year | 3 / 6 | Cited 7.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 2 / 4 | Cited 44 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Amy L. Brewster: h-index 29 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Purdue University West Lafayette: institution h-index 983 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28601603) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Wyatt, S. K., Witt, T., Barbaro, N. M., Cohen-Gadol, A. A., & Brewster, A. L. (2017). Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy. Experimental neurology. https://doi.org/10.1016/j.expneurol.2017.06.009
Vancouver
Wyatt SK, Witt T, Barbaro NM, Cohen-Gadol AA, Brewster AL. Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy. Experimental neurology. 2017. doi:10.1016/j.expneurol.2017.06.009. PMID: 28601603.
BibTeX
@article{wyatt2017-28601603,
author = {Wyatt, S. K. and Witt, T. and Barbaro, N. M. and Cohen-Gadol, A. A. and Brewster, A. L.},
title = {{Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy}},
journal = {Experimental neurology},
year = {2017},
doi = {10.1016/j.expneurol.2017.06.009},
pmid = {28601603},
url = {https://doi.org/10.1016/j.expneurol.2017.06.009}
}
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