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Cerebral Perfusion and the Risk of Dementia: A Population-Based Study
Wolters FJ, Zonneveld HI, Hofman A, van der Lugt A, Koudstaal PJ, Vernooij MW, Ikram MA, Heart-Brain Connection Collaborative Research Group.. Circulation, 2017-06-06
Topic: Risk, prevention and care in population studies
Background Cerebral hypoperfusion has previously been associated with mild cognitive impairment and dementia in various cross-sectional studies, but whether hypoperfusion precedes neurodegeneration is unknown. We prospectively determined the association of cerebral perfusion with subsequent cognitive decline and development of dementia. Methods Between 2005 and 2012, we measured cerebral blood flow by 2-dimensional phase-contrast magnetic resonance imaging in participants of the population-based Rotterdam Study without dementia.
Key findings
- We prospectively determined the association of cerebral perfusion with subsequent cognitive decline and development of dementia.
- Methods Between 2005 and 2012, we measured cerebral blood flow by 2-dimensional phase-contrast magnetic resonance imaging in participants of the population-based Rotterdam Study without dementia.
- We determined the association of cerebral perfusion (mL/100mL/min) with risk of dementia (until 2015) using a Cox model, adjusting for age, sex, demographics, cardiovascular risk factors, and apolipoprotein E genotype.
- We repeated analyses for Alzheimer disease and accounting for stroke.
Why it matters
This study measured blood flow in the brain and then followed participants to see who developed dementia, to test whether reduced blood flow comes before cognitive decline. If poor brain perfusion precedes dementia, it could be a target for prevention, but this study only examined the association over time.
Study details
- Study designcross-sectional
- Participants4,759
- Effect size55.2%
- Evidence strengthLow
How this study scored 67/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Circulation) |
| Journal's citation record | 4 / 4 | Circulation: journal h-index 848 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 3 / 4 | 4,759 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 520 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 47.3 citations a year over 11 year(s) since 2017 |
| Impact for its field and year | 5 / 6 | Cited 27.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 14 other studies in this library |
| Still being cited | 3 / 4 | Cited 172 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author M. Arfan Ikram: h-index 167 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28588075) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 67 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1161/circulationaha.117.027448
- PubMed: 28588075
- Original source →
- Free full text: Circulation →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Wolters, F. J., Zonneveld, H. I., Hofman, A., van der Lugt, A., Koudstaal, P. J., Vernooij, M. W., et al. (2017). Cerebral Perfusion and the Risk of Dementia: A Population-Based Study. Circulation. https://doi.org/10.1161/circulationaha.117.027448
Vancouver
Wolters FJ, Zonneveld HI, Hofman A, van der Lugt A, Koudstaal PJ, Vernooij MW, et al. Cerebral Perfusion and the Risk of Dementia: A Population-Based Study. Circulation. 2017. doi:10.1161/circulationaha.117.027448. PMID: 28588075.
BibTeX
@article{wolters2017-28588075,
author = {Wolters, F. J. and Zonneveld, H. I. and Hofman, A. and van der Lugt, A. and Koudstaal, P. J. and Vernooij, M. W. and Ikram, M. A. and {Heart-Brain Connection Collaborative Research Group}},
title = {{Cerebral Perfusion and the Risk of Dementia: A Population-Based Study}},
journal = {Circulation},
year = {2017},
doi = {10.1161/circulationaha.117.027448},
pmid = {28588075},
url = {https://doi.org/10.1161/circulationaha.117.027448}
}
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