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Concordance between brain 18F-FDG PET and cerebrospinal fluid biomarkers in diagnosing Alzheimer's disease
Rubí S, Noguera A, Tarongí S, Oporto M, García A, Vico H, Espino A, Picado MJ et al.. Revista espanola de medicina nuclear e imagen molecular, 2017-06-20
Topic: Amyloid, tau and blood-test diagnosis
Objectives Cortical posterior hypometabolism on PET imaging with 18 F-FDG (FDG-PET), and altered levels of Aß 1-42 peptide, total Tau (tTau) and phosphorylated Tau (pTau) proteins in cerebrospinal fluid (CSF) are established diagnostic biomarkers in Alzheimer's disease (AD). An evaluation has been made of the concordance and relationship between the results of FDG-PET and CSF biomarkers in symptomatic patients with suspected AD. Material and methods A retrospective review was carried out on 120 patients with cognitive impairment referred to our Cognitive Neurology Unit, and who were evaluated by brain FDG-PET and a lumbar puncture for CSF biomarkers.
Key findings
- An evaluation has been made of the concordance and relationship between the results of FDG-PET and CSF biomarkers in symptomatic patients with suspected AD.
- Material and methods A retrospective review was carried out on 120 patients with cognitive impairment referred to our Cognitive Neurology Unit, and who were evaluated by brain FDG-PET and a lumbar puncture for CSF biomarkers.
- In order to calculate their Kappa coefficient of concordance, the result of the FDG-PET and the set of the three CSF biomarkers in each patient was classified as normal, inconclusive, or AD-compatible.
- The relationship between the results of both methods was further assessed using logistic regression analysis, including the Aß 1-42 , tTau and pTau levels as quantitative predictors, and the FDG-PET result as the dependent variable.
Why it matters
This retrospective review of 120 patients with cognitive impairment assessed how well brain FDG-PET and cerebrospinal fluid biomarkers agree when diagnosing Alzheimer's disease. It is about diagnostic agreement between tests, not about treating, curing or preventing the disease.
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Study details
- Participants120
- Evidence strengthLow
How this study scored 33/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Revista espanola de medicina nuclear e imagen molecular) |
| Journal's citation record | 0 / 4 | Revista Española de Medicina Nuclear e Imagen Molecular: journal h-index 22 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 120 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 9 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.9 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 1 / 6 | Cited 0.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Guillem Amer: h-index 7 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Hospital Universitario Son Espases: institution h-index 176 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28645685) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 33 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Rubí, S., Noguera, A., Tarongí, S., Oporto, M., García, A., Vico, H., et al. (2018). Concordance between brain 18F-FDG PET and cerebrospinal fluid biomarkers in diagnosing Alzheimer's disease. Revista espanola de medicina nuclear e imagen molecular. https://doi.org/10.1016/j.remn.2017.05.003
Vancouver
Rubí S, Noguera A, Tarongí S, Oporto M, García A, Vico H, et al. Concordance between brain 18F-FDG PET and cerebrospinal fluid biomarkers in diagnosing Alzheimer's disease. Revista espanola de medicina nuclear e imagen molecular. 2018. doi:10.1016/j.remn.2017.05.003. PMID: 28645685.
BibTeX
@article{rubi2018-28645685,
author = {Rubí, S. and Noguera, A. and Tarongí, S. and Oporto, M. and García, A. and Vico, H. and Espino, A. and Picado, M. J. and others},
title = {{Concordance between brain 18F-FDG PET and cerebrospinal fluid biomarkers in diagnosing Alzheimer's disease}},
journal = {Revista espanola de medicina nuclear e imagen molecular},
year = {2018},
doi = {10.1016/j.remn.2017.05.003},
pmid = {28645685},
url = {https://doi.org/10.1016/j.remn.2017.05.003}
}
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