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67/100

✓ Peer-reviewed alzhub usefulness score 67 out of 100. Mild cognitive impairment

Topic: Risk, prevention and care in population studies

Background We aimed to describe the Subjective Cognitive Impairment Cohort (SCIENCe) study design, to cross-sectionally describe participant characteristics, and to evaluate the SCD-plus criteria. Methods The SCIENCe is a prospective cohort study of subjective cognitive decline (SCD) patients. Participants undergo extensive assessment, including cerebrospinal fluid collection and optional amyloid positron emission tomography scan, with annual follow-up. The primary outcome measure is clinical progression. Results Cross-sectional evaluation of the first 151 participants (age 64 ± 8, 44% female, Mini-Mental State Examination 29 ± 2) showed that 28 (25%) had preclinical Alzheimer's disease (AD) (amyloid status available n = 114 (75%)), 58 (38%) had subthreshold psychiatry, and 65 (43%) had neither. More severe subjective complaints were associated with worse objective performance. The SCD-plus criteria age ≥ 60 (OR 7.7 (95% CI 1.7-38.9)) and apolipoprotein E (genotype) e4 (OR 4.8 (95% CI 1.6-15.0)) were associated with preclinical AD. Conclusions The SCIENCe study confirms that SCD is a heterogeneous group, with preclinical AD and subthreshold psychiatric features. We found a number of SCD-plus criteria to be associated with preclinical AD. Further inclusion and follow-up will address important questions related to SCD.

Key findings

Results Cross-sectional evaluation of the first 151 participants (age 64 ± 8, 44% female, Mini-Mental State Examination 29 ± 2) showed that 28 (25%) had preclinical Alzheimer's disease (AD) (amyloid status available n = 114 (75%)), 58 (38%) had subthreshold psychiatry, and 65 (43%) had neither.
More severe subjective complaints were associated with worse objective performance.
The SCD-plus criteria age ≥ 60 (OR 7.7 (95% CI 1.7-38.9)) and apolipoprotein E (genotype) e4 (OR 4.8 (95% CI 1.6-15.0)) were associated with preclinical AD.
We found a number of SCD-plus criteria to be associated with preclinical AD.

Why it matters

This cohort study describes the design and first results of a study of patients with subjective cognitive decline. It found that this group is heterogeneous, with some having preclinical Alzheimer's disease and others having subthreshold psychiatric features, and that certain criteria were associated with preclinical Alzheimer's disease.

Study details

Study designcohort study
Participants114
Effect sizeOR 7.7 (95% CI 1.7-38.9); OR 4.8 (95% CI 1.6-15.0)
Evidence strengthModerate

How this study scored 67/100

Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer's research & therapy)
Journal's citation record	1 / 4	Alzheimer s Research & Therapy: journal h-index 146 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2018 — within 10 year(s) of the newest study here
Sample size	2 / 4	114 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 132 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	13.2 citations a year over 10 year(s) since 2018
Impact for its field and year	4 / 6	Cited 9.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 19 other studies in this library
Still being cited	2 / 4	Cited 39 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Wiesje M. van der Flier: h-index 132 (OpenAlex, whole career)
Institution's track record	2 / 3	University College London: institution h-index 2,029 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 6 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 30081935)
Free to read	2 / 2	Free to read
Total	67 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Slot, R. E. R., Verfaillie, S. C. J., Overbeek, J. M., Timmers, T., Wesselman, L. M. P., Teunissen, C. E., et al. (2018). Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results. Alzheimer's research & therapy. https://doi.org/10.1186/s13195-018-0390-y

Vancouver

Slot RER, Verfaillie SCJ, Overbeek JM, Timmers T, Wesselman LMP, Teunissen CE, et al. Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results. Alzheimer's research & therapy. 2018. doi:10.1186/s13195-018-0390-y. PMID: 30081935.

BibTeX

@article{slot2018-30081935,
  author  = {Slot, R. E. R. and Verfaillie, S. C. J. and Overbeek, J. M. and Timmers, T. and Wesselman, L. M. P. and Teunissen, C. E. and Dols, A. and Bouwman, F. H. and others},
  title   = {{Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results}},
  journal = {Alzheimer's research \& therapy},
  year    = {2018},
  doi     = {10.1186/s13195-018-0390-y},
  pmid    = {30081935},
  url     = {https://doi.org/10.1186/s13195-018-0390-y}
}

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