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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 25,851–25,875 of 27,380 studies, newest first · page 1035 of 1096.

December 1998 9

  1. 1998-12-01

    Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

    ✓ Peer-reviewed Tau biomarkers The Journal of biological chemistry

    Key finding: In addition to its ability to degrade Abeta, IDE activity was unexpectedly found be associated with a time-dependent oligomerization of synthetic Abeta at physiological levels in the conditioned media of cultured cells; this process, which may be initiated by IDE-generated proteolytic fragments of Abeta, was prevented by three different IDE inhibitors. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 1998-12-01

    Neurology and the kidney

    ✓ Peer-reviewed Clinical safety Journal of neurology, neurosurgery, and psychiatry

    Key finding: Renal failure is relatively common, but except in association with spina bifida or paraplegia it is unlikely to occur as a result of disease of the CNS. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 1998-12-01

    Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: The principal component of amyloid deposits is beta amyloid peptide (Abeta), a peptide derived by proteolytic processing of the amyloid precursor protein (APP). +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 1998-12-01

    Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17

    ✓ Peer-reviewed Lewy body dementia Science (New York, N.Y.)

    Key finding: Analyses of soluble and insoluble tau proteins from brains of FTDP-17 patients indicated that different pathogenic mutations differentially altered distinct biochemical properties and stoichiometry of brain tau isoforms.

    Full summary, score breakdown and related studies → Original source

  5. 1998-12-01

    Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria

    ✓ Peer-reviewed Lewy body dementia Neurology

    Key finding: The criteria ought to provide the foundation for research work into the neuropsychology, neuropathology, genetics, molecular biology, and epidemiology of these important clinical disorders that account for a substantial proportion of cases of primary degenerative dementia occurring before the age of 65 years. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 1998-12-01

    Extracellular neurofibrillary tangles are immunopositive for the 40 carboxy-terminal sequence of beta-amyloid protein

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neuropathology and experimental neurology

    Key finding: Reports on whether NFTs have Abeta associated with them are inconsistent. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 1998-12-01

    Biomarkers of oxidative stress are significantly elevated in Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Free radical biology & medicine

    Key finding: The incidence of autoimmune diseases and cataracts is significantly increased, and the overall ageing process is accelerated. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 1998-12-01

    Episodes of lucidity in people with severe dementia as narrated by formal carers

    ✓ Peer-reviewed Digital health tools Journal of advanced nursing

    Key finding: Twenty formal carers employed in three nursing homes narrated 92 episodes of lucidity (ELs) in people with severe dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 1998-12-01

    Depressive symptomatology in first-degree family caregivers of Alzheimer disease patients: a cross-ethnic comparison

    ✓ Peer-reviewed Disparities Alzheimer disease and associated disorders

    Key finding: Overall, depression (CES-D scores > or = 16) was more common among WH (45%) than among WNH (36%) caregivers (p < 0.05).

    Full summary, score breakdown and related studies → Original source

November 1998 16

  1. 1998-11-01

    Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes

    ✓ Peer-reviewed Brain tissue and pathology American Journal Of Pathology

    Key finding: Furthermore, alpha-synuclein antibodies decorated LB filaments by immunoelectron microscopy, and Western blots revealed that the solubility of alpha-synuclein was reduced compared with control brains. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 1998-11-01

    Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEs

    ✓ Peer-reviewed Vascular contributions PubMed

    Key finding: Cell activation in response to AGE-modified proteins is associated with increased expression of extracellular matrix proteins, vascular adhesion molecules, cytokines and growth factors. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 1998-11-01

    Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms The Journal of cell biology

    Key finding: Mitochondria fail to be transported to peripheral cell compartments and cluster in the vicinity of the microtubule-organizing center. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 1998-11-01

    Glutamate in CNS disorders as a target for drug development: an update

    ✓ Peer-reviewed Risk factors Drug news & perspectives

    Key finding: The authors provide an extensive review of new data related to the role of glutamate in CNS disorders, describing new aspects in glutamate and glutamatergic receptors-NMDA receptors, NR2B-selective antagonists, non-NMDA ionotropic glutamate receptors, N-acetylaspartylglutamate, and glutamate and glycine transporters. +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 1998-11-01

    Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau

    ✓ Peer-reviewed Drug development The American journal of pathology

    Key finding: Numerous intracytoplasmic tau deposits in neurons, glial cells, and neurites were found in hippocampal formation, neocortex, and substantia nigra. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 1998-11-01

    The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

    ✓ Peer-reviewed Risk genes beyond APOE Trends in cell biology

    Key finding: It is a truism of modern biomedical science that the development of therapies expected to slow or arrest the progression of a disease requires as detailed an understanding of its molecular and cellular pathogenesis as possible. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 1998-11-01

    Regional changes in hippocampal T2 relaxation and volume: a quantitative magnetic resonance imaging study of hippocampal sclerosis

    ✓ Peer-reviewed Hippocampus size on brain scans Journal of neurology, neurosurgery, and psychiatry

    Key finding: Measurement of regional abnormalities of HT2 along the length of the hippocampus provides further refinement to the MRI assessment of the hippocampi in patients with temporal lobe epilepsy and is complementary to volumetric and morphological data.

    Full summary, score breakdown and related studies → Original source

  8. 1998-11-01

    Young-onset Parkinson's disease revisited--clinical features, natural history, and mortality

    ✓ Peer-reviewed Clinical safety Movement disorders : official journal of the Movement Disorder Society

    Key finding: The authors conclude that the mortality rate in parkinsonism starting before the age of 40 is increased in comparison to the normal population and is similar to the general Parkinson's disease population.

    Full summary, score breakdown and related studies → Original source

  9. 1998-11-01

    HIV encephalitis, proviral load and dementia in drug users and homosexuals with AIDS. Effect of neocortical involvement

    ✓ Peer-reviewed Inflammation and the immune system Brain : a journal of neurology

    Key finding: These findings suggest that neocortical productive HIV infection is a significant factor in AIDS-related dementia, although this may reflect merely a higher overall viral burden in the brain.

    Full summary, score breakdown and related studies → Original source

  10. 1998-11-01

    Cerebral glucose metabolism in patients with frontotemporal dementia

    ✓ Peer-reviewed Cognitive tests and assessment Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    Key finding: Frontotemporal dementia (FTD) is a dementia syndrome characterized by peculiar behavioral changes arising from frontotemporal involvement and distinct from Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 1998-11-01

    Generation and regulation of beta-amyloid peptide variants by neurons

    ✓ Peer-reviewed Risk genes beyond APOE Journal of neurochemistry

    Key finding: To determine whether similar processing events underlie betaAPP metabolism in neurons, media were examined following conditioning by primary neuronal cultures derived from embryonic day 17 rats. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 1998-11-01

    Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE Journal of neuropathology and experimental neurology

    Key finding: The main objective of the present study was to determine if deficient GT functioning in AD could be associated with cell damage and caspase activation. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 1998-11-01

    Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

    ✓ Peer-reviewed Lewy body dementia Nature medicine

    Key finding: This connection between genetics and pathology suggests that the alpha-synuclein mutations may promote PD pathogenesis by accelerating Lewy body formation.

    Full summary, score breakdown and related studies → Original source

  14. 1998-11-01

    Long-term basal forebrain cholinergic-rich grafts derived from trisomy 16 mice do not develop beta-amyloid pathology and neurodegeneration but demonstrate neuroinflammatory responses

    ✓ Peer-reviewed Down syndrome and Alzheimer's International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

    Key finding: Grafts survived up to one year and still demonstrated immunoreactivity for cholinergic, GABAergic and astroglial cells. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 1998-11-01

    Microglial activation induced by factor(s) contained in sera from Alzheimer-related ApoE genotypes

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neuroscience research

    Key finding: The risk of developing AD definitely increases with (a) age, (b) head injuries, (c) family history of AD or Down syndrome, (d) sex (higher prevalence of AD in women), (e) vascular disease, (f) exposure to environmental toxins, (g) infectious processes, or (h) changes in immune function, and recent advances in molecular genetics have suggested that genetic predisposition (i) can be considered one of the most important risk factors in the development of AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 1998-11-01

    Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neuropathology and experimental neurology

    Key finding: The abundance of the distinct forms of A beta reported here in formic acid extracts of AD and DS frontal cortex suggests that these A beta species could play important roles in the deposition of A beta in AD and DS brains.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →