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Age-related hearing loss accelerates cerebrospinal fluid tau levels and brain atrophy: a longitudinal study
Xu W, Zhang C, Li JQ, Tan CC, Cao XP, Tan L, Yu JT, Alzheimer’s Disease Neuroimaging Initiative.. Aging, 2019-05-01
Topic: Brain proteins, microglia and lab models
Age-related hearing loss (ARHL) has been considered as a promising modifiable risk factor for cognitive impairment and dementia. Nonetheless, it is still unclear whether age-related hearing loss associates with neurodegenerative biomarkers of Alzheimer's disease (AD). Participants with ARHL were selected from the established Alzheimer's Disease Neuroimaging Initiative (ADNI) database.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Xu, W., Zhang, C., Li, J. Q., Tan, C. C., Cao, X. P., Tan, L., et al. (2019). Age-related hearing loss accelerates cerebrospinal fluid tau levels and brain atrophy: a longitudinal study. Aging. https://doi.org/10.18632/aging.101971
Vancouver
Xu W, Zhang C, Li JQ, Tan CC, Cao XP, Tan L, et al. Age-related hearing loss accelerates cerebrospinal fluid tau levels and brain atrophy: a longitudinal study. Aging. 2019. doi:10.18632/aging.101971. PMID: 31118310.
BibTeX
@article{xu2019-31118310,
author = {Xu, W. and Zhang, C. and Li, J. Q. and Tan, C. C. and Cao, X. P. and Tan, L. and Yu, J. T. and {Alzheimer’s Disease Neuroimaging Initiative}},
title = {{Age-related hearing loss accelerates cerebrospinal fluid tau levels and brain atrophy: a longitudinal study}},
journal = {Aging},
year = {2019},
doi = {10.18632/aging.101971},
pmid = {31118310},
url = {https://doi.org/10.18632/aging.101971}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Nonetheless, it is still unclear whether age-related hearing loss associates with neurodegenerative biomarkers of Alzheimer's disease (AD).
- Participants with ARHL were selected from the established Alzheimer's Disease Neuroimaging Initiative (ADNI) database.
- In multivariable models, the cross-sectional and longitudinal associations of ARHL with CSF β-amyloid (Aβ) and tau measurements, brain Aβ load, and cortical structural measures were explored.
- ARHL was associated with higher CSF levels of tau (p < 0.001) or ptau181 (p < 0.05) at baseline as well as faster elevation rates of these two types of biomarkers (p < 0.05).
Why it matters
This study found that age-related hearing loss was associated with higher cerebrospinal fluid tau levels and brain atrophy over time. It does not show that treating hearing loss prevents dementia, and the findings are from an observational study of biomarkers.
Study details
- Study designcross-sectional
- Evidence strengthModerate
How this study scored 54/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Aging) |
| Journal's citation record | 2 / 4 | Aging: journal h-index 162 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 75 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.3 citations a year over 9 year(s) since 2019 |
| Impact for its field and year | 3 / 6 | Cited 5.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 2 / 4 | Cited 32 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Jin‐Tai Yu: h-index 94 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31118310) |
| Free to read | 2 / 2 | Free to read |
| Total | 54 / 100 | — |
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