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Familial Alzheimer's disease presenilin-2 mutants affect Ca2+ homeostasis and brain network excitability
Diana Pendin, Cristina Fasolato, Emy Basso, Riccardo Filadi, Elisa Greotti, Luisa Galla, Chiara Gomiero, Alessandro Leparulo et al.. Aging clinical and experimental research, 2019-10-12
Topic: Disease mechanisms in lab and animal studies
Alzheimer's disease (AD) is the most frequent cause of dementia in the elderly. Few cases are familial (FAD), due to autosomal dominant mutations in presenilin-1 (PS1), presenilin-2 (PS2) or amyloid precursor protein (APP). The three proteins are involved in the generation of amyloid-beta (Aβ) peptides, providing genetic support to the hypothesis of Aβ pathogenicity. However, clinical trials focused on the Aβ pathway failed in their attempt to modify disease progression, suggesting the existence of additional pathogenic mechanisms. Ca2+ dysregulation is a feature of cerebral aging, with an increased frequency and anticipated age of onset in several forms of neurodegeneration, including AD. Interestingly, FAD-linked PS1 and PS2 mutants alter multiple key cellular pathways, including Ca2+ signaling. By generating novel tools for measuring Ca2+ in living cells, and combining different approaches, we showed that FAD-linked PS2 mutants significantly alter cell Ca2+ signaling and brain network activity, as summarized below.
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APA 7th
Pendin, D., Fasolato, C., Basso, E., Filadi, R., Greotti, E., Galla, L., et al. (2021). Familial Alzheimer's disease presenilin-2 mutants affect Ca2+ homeostasis and brain network excitability. Aging clinical and experimental research. https://doi.org/10.1007/s40520-019-01341-0
Vancouver
Pendin D, Fasolato C, Basso E, Filadi R, Greotti E, Galla L, et al. Familial Alzheimer's disease presenilin-2 mutants affect Ca2+ homeostasis and brain network excitability. Aging clinical and experimental research. 2021. doi:10.1007/s40520-019-01341-0. PMID: 31606858.
BibTeX
@article{pendin2021-31606858,
author = {Pendin, Diana and Fasolato, Cristina and Basso, Emy and Filadi, Riccardo and Greotti, Elisa and Galla, Luisa and Gomiero, Chiara and Leparulo, Alessandro and others},
title = {{Familial Alzheimer's disease presenilin-2 mutants affect Ca2+ homeostasis and brain network excitability}},
journal = {Aging clinical and experimental research},
year = {2021},
doi = {10.1007/s40520-019-01341-0},
pmid = {31606858},
url = {https://doi.org/10.1007/s40520-019-01341-0}
}
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Key findings
- By generating novel tools for measuring Ca2+ in living cells, and combining different approaches, we showed that FAD-linked PS2 mutants significantly alter cell Ca2+ signaling and brain network activity, as summarized below.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 23 of the 56 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Aging clinical and experimental research) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31606858) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 23 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 23 of the 56 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
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