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68/100

✓ Peer-reviewed alzhub usefulness score 68 out of 100. Biomarkers

Topic: Plasma and spinal-fluid biomarkers

Presence on T2-weighted images of white matter hyperintensities (WMH) has been previously shown to be more commonly associated with GRN mutations rather than other forms of FTD. Analyses revealed that WMH load was higher in both symptomatic and presymptomatic groups compared with controls and this load increased over time. GM atrophy was strongly associated with WMH load both globally and in separate lobes, and increased WMH burden in the frontal, periventricular and medial regions was associated with worse executive function. Furthermore, plasma NfL and to a lesser extent GFAP concentrations were seen to be associated with increased lesion burden. Lastly, the presence of the homozygous TMEM106B rs1990622 TT risk genotypic status was associated with an increased accrual of WMH per year. They are associated with increased GM atrophy and executive dysfunction. Furthermore, their presence is associated with markers of WM damage (NfL) and astrocytosis (GFAP), whilst their accrual is modified by TMEM106B genetic status.

Key findings

Presence on T2-weighted images of white matter hyperintensities (WMH) has been previously shown to be more commonly associated with GRN mutations rather than other forms of FTD.
Analyses revealed that WMH load was higher in both symptomatic and presymptomatic groups compared with controls and this load increased over time.
GM atrophy was strongly associated with WMH load both globally and in separate lobes, and increased WMH burden in the frontal, periventricular and medial regions was associated with worse executive function.
Furthermore, plasma NfL and to a lesser extent GFAP concentrations were seen to be associated with increased lesion burden.
Lastly, the presence of the homozygous TMEM106B rs1990622 TT risk genotypic status was associated with an increased accrual of WMH per year.

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Study details

Study designlongitudinal study
Participants336
Effect size25.0%; 37.5%
Evidence strengthModerate

How this study scored 68/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 38 of the 56 points we could judge it on, which is 68 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (NeuroImage. Clinical)
Journal's citation record	— / 4	No journal record from OpenAlex — left out of this score
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2019 — within 10 year(s) of the newest study here
Sample size	2 / 4	336 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	— / 7	No citation count (not found in OpenAlex) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	— / 6	Not yet checked against this library's citation graph — left out of this score
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multi-centre collaboration	— / 3	Institutions not listed — left out of this score
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 31835286)
Free to read	— / 2	Access not recorded — left out of this score
Points	38 / 56	Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 38 of the 56 points we could judge it on is 68 out of 100.
Total	68 / 100	—

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

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APA 7th

Sudre, C. H., Bocchetta, M., Heller, C., Convery, R., Neason, M., Moore, K. M., et al. (2019). White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study. NeuroImage. Clinical. https://doi.org/10.1016/j.nicl.2019.102077

Vancouver

Sudre CH, Bocchetta M, Heller C, Convery R, Neason M, Moore KM, et al. White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study. NeuroImage. Clinical. 2019. doi:10.1016/j.nicl.2019.102077. PMID: 31835286.

BibTeX

@article{sudre2019-31835286,
  author  = {Sudre, Carole H and Bocchetta, Martina and Heller, Carolin and Convery, Rhian and Neason, Mollie and Moore, Katrina M and Cash, David M and Thomas, David L and others},
  title   = {{White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study}},
  journal = {NeuroImage. Clinical},
  year    = {2019},
  doi     = {10.1016/j.nicl.2019.102077},
  pmid    = {31835286},
  url     = {https://doi.org/10.1016/j.nicl.2019.102077}
}

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