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67/100

✓ Peer-reviewed alzhub usefulness score 67 out of 100. Long-term cohort studies

Topic: Risk, prevention and care in population studies

Importance Midlife vascular risk burden is associated with late-life dementia. Less is known about if and how risk exposure in early adulthood influences late-life brain health. Objective To determine the associations between vascular risk in early adulthood, midlife, and late life with late-life brain structure and pathology using measures of white matter-hyperintensity volume, β-amyloid load, and whole-brain and hippocampal volumes.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Lane, C. A., Barnes, J., Nicholas, J. M., Sudre, C. H., Cash, D. M., Malone, I. B., et al. (2020). Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort. JAMA neurology. https://doi.org/10.1001/jamaneurol.2019.3774

Vancouver

Lane CA, Barnes J, Nicholas JM, Sudre CH, Cash DM, Malone IB, et al. Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort. JAMA neurology. 2020. doi:10.1001/jamaneurol.2019.3774. PMID: 31682678.

BibTeX

@article{lane2020-31682678,
  author  = {Lane, C. A. and Barnes, J. and Nicholas, J. M. and Sudre, C. H. and Cash, D. M. and Malone, I. B. and Parker, T. D. and Keshavan, A. and others},
  title   = {{Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2019.3774},
  pmid    = {31682678},
  url     = {https://doi.org/10.1001/jamaneurol.2019.3774}
}

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Key findings

Less is known about if and how risk exposure in early adulthood influences late-life brain health.
Objective To determine the associations between vascular risk in early adulthood, midlife, and late life with late-life brain structure and pathology using measures of white matter-hyperintensity volume, β-amyloid load, and whole-brain and hippocampal volumes.
Design, setting, and participants This prospective longitudinal cohort study, Insight 46, is part of the Medical Research Council National Survey of Health and Development, which commenced in 1946.
Participants had vascular risk factors evaluated at ages 36 years (early adulthood), 53 years (midlife), and 69 years (early late life).

Why it matters

This British birth cohort study examined whether vascular risk in early adulthood, midlife and late life is associated with late-life brain structure and pathology. It reports associations with brain measures, so it does not show that modifying vascular risk prevents or treats Alzheimer's disease.

Study details

Study designcohort study
Participants502
Effect size51.0%; 18.2%; 2.7%
Evidence strengthModerate

How this study scored 67/100

Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2020 — within 10 year(s) of the newest study here
Sample size	2 / 4	502 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 104 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	13.0 citations a year over 8 year(s) since 2020
Impact for its field and year	3 / 6	Cited 7.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 12 other studies in this library
Still being cited	2 / 4	Cited 45 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Jonathan M. Schott: h-index 96 (OpenAlex, whole career)
Institution's track record	2 / 3	University College London: institution h-index 2,029 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 7 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 31682678)
Free to read	2 / 2	Free to read
Total	67 / 100	—

What each of these 20 components measures, and what this score is not →

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