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Upregulation of neuronal PGC-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion
Han B, Jiang W, Liu H, Wang J, Zheng K, Cui P, Feng Y, Dang C et al.. Theranostics, 2020-02-03
Topic: Brain proteins, microglia and lab models
Plain-language summary
Rationale : Mitochondrial dysfunction and oxidative stress occur in vascular dementia (VaD), but the specific molecular mechanism regulating these events remains unclear. Peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) is a master regulator for mitochondrial function. This study aims to investigate whether PGC-1α is involved in the pathophysiology of VaD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Han, B., Jiang, W., Liu, H., Wang, J., Zheng, K., Cui, P., et al. (2020). Upregulation of neuronal PGC-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion. Theranostics. https://doi.org/10.7150/thno.37119
Vancouver
Han B, Jiang W, Liu H, Wang J, Zheng K, Cui P, et al. Upregulation of neuronal PGC-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion. Theranostics. 2020. doi:10.7150/thno.37119. PMID: 32194838.
BibTeX
@article{han2020-32194838,
author = {Han, B. and Jiang, W. and Liu, H. and Wang, J. and Zheng, K. and Cui, P. and Feng, Y. and Dang, C. and others},
title = {{Upregulation of neuronal PGC-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion}},
journal = {Theranostics},
year = {2020},
doi = {10.7150/thno.37119},
pmid = {32194838},
url = {https://doi.org/10.7150/thno.37119}
}
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Key findings
- Peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) is a master regulator for mitochondrial function.
- This study aims to investigate whether PGC-1α is involved in the pathophysiology of VaD.
- Methods : We firstly generated PGC-1α f/f Eno2-Cre mice to induce neuron-specific overexpression of PGC-1α by crossbreeding PGC-1α f/f mice with Eno2-cre mice.
- Then, the mice were subjected to bilateral common carotid artery stenosis to induce chronic cerebral hypoperfusion.
Why it matters
Mice with neuron-specific overexpression of PGC-1alpha were subjected to bilateral common carotid artery stenosis to induce chronic cerebral hypoperfusion, and the study investigated whether PGC-1alpha is involved in the pathophysiology of vascular dementia. This is an animal study of vascular dementia, not a demonstrated treatment or cure for Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 51/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Theranostics) |
| Journal's citation record | 2 / 4 | Theranostics: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 173 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 21.6 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 3 / 6 | Cited 6.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 3 / 4 | Cited 97 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Junwei Hao: h-index 50 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32194838) |
| Free to read | 2 / 2 | Free to read |
| Total | 51 / 100 | — |
What each of these 20 components measures, and what this score is not →
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