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53/100

✓ Peer-reviewed alzhub usefulness score 53 out of 100. Long-term cohort studies

Topic: Amyloid, tau and blood-test diagnosis

Background We evaluated the role of cortical amyloid deposition as a factor contributing to memory dysfunction and increased risk of dementia associated with late-life depression (LLD). Methods A total of 119 older adult participants with a current diagnosis of major depression (LLD) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) Depression Project study and 119 nondepressed (ND) cognitively unimpaired participants matched on age, sex, and APOE genotype were obtained from the ADNI database. Results Thirty-three percent of LLD participants met ADNI criteria for mild cognitive impairment.

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APA 7th

Mackin, R. S., Insel, P. S., Landau, S., Bickford, D., Morin, R., Rhodes, E., et al. (2021). Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden: Findings From the Alzheimer's Disease Neuroimaging Initiative Depression Project. Biological psychiatry. https://doi.org/10.1016/j.biopsych.2020.06.017

Vancouver

Mackin RS, Insel PS, Landau S, Bickford D, Morin R, Rhodes E, et al. Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden: Findings From the Alzheimer's Disease Neuroimaging Initiative Depression Project. Biological psychiatry. 2021. doi:10.1016/j.biopsych.2020.06.017. PMID: 32980132.

BibTeX

@article{mackin2021-32980132,
  author  = {Mackin, R. S. and Insel, P. S. and Landau, S. and Bickford, D. and Morin, R. and Rhodes, E. and Tosun, D. and Rosen, H. J. and others},
  title   = {{Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden: Findings From the Alzheimer's Disease Neuroimaging Initiative Depression Project}},
  journal = {Biological psychiatry},
  year    = {2021},
  doi     = {10.1016/j.biopsych.2020.06.017},
  pmid    = {32980132},
  url     = {https://doi.org/10.1016/j.biopsych.2020.06.017}
}

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Key findings

Methods A total of 119 older adult participants with a current diagnosis of major depression (LLD) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) Depression Project study and 119 nondepressed (ND) cognitively unimpaired participants matched on age, sex, and APOE genotype were obtained from the ADNI database.
Results Thirty-three percent of LLD participants met ADNI criteria for mild cognitive impairment.
Compared with ND individuals, the LLD group exhibited less global amyloid beta (Aβ) accumulation (p = .05).
The proportion of amyloid positivity in the LLD group was 19.3% compared with 31.1% for the ND participants (p = .02).

Why it matters

In 119 older adults with late-life depression compared with 119 nondepressed participants, the depressed group had less global amyloid beta accumulation. Thirty-three percent of the depressed participants met criteria for mild cognitive impairment, suggesting that amyloid may not be the main driver of memory problems in late-life depression.

Study details

Participants119
Effect size19.3%; 31.1%
Evidence strengthLow

How this study scored 53/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Biological psychiatry)
Journal's citation record	3 / 4	Biological Psychiatry: journal h-index 428 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2021 — within 6 year(s) of the newest study here
Sample size	2 / 4	119 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 76 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	10.9 citations a year over 7 year(s) since 2021
Impact for its field and year	3 / 6	Cited 5.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 4 other studies in this library
Still being cited	2 / 4	Cited 39 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Craig J. Nelson: h-index 18 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Michigan: institution h-index 2,240 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 10 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 32980132)
Free to read	0 / 2	Behind a paywall — scores zero
Total	53 / 100	—

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