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Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly
Jordi Pegueroles, Adriana Pané, Eduard Vilaplana, Víctor Montal, Alexandre Bejanin, Laura Videla, María Carmona-Iragui, Isabel Barroeta et al.. Alzheimer's & dementia (Amsterdam, Netherlands), 2020-07-28
Topic: Plasma and spinal-fluid biomarkers
We included 201 individuals (mean age 73.5 years, mean BMI 27.4 kg/m2). Higher BMI was related to less cortical thickness and higher metabolism in brain areas typically not involved in AD (family-wise error [FWE] <0.05), but not to AD CSF biomarkers. It is notable that the impact of obesity on brain metabolism and structure was also found in amyloid negative individuals. CONCLUSIONS/ In the cognitively unimpaired elderly, obesity has differential effects on brain metabolism and structure independent of an underlying AD pathophysiology.
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APA 7th
Pegueroles, J., Pané, A., Vilaplana, E., Montal, V., Bejanin, A., Videla, L., et al. (2020). Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly. Alzheimer's & dementia (Amsterdam, Netherlands). https://doi.org/10.1002/dad2.12052
Vancouver
Pegueroles J, Pané A, Vilaplana E, Montal V, Bejanin A, Videla L, et al. Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly. Alzheimer's & dementia (Amsterdam, Netherlands). 2020. doi:10.1002/dad2.12052. PMID: 32743041.
BibTeX
@article{pegueroles2020-32743041,
author = {Pegueroles, Jordi and Pané, Adriana and Vilaplana, Eduard and Montal, Víctor and Bejanin, Alexandre and Videla, Laura and Carmona-Iragui, María and Barroeta, Isabel and others},
title = {{Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly}},
journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
year = {2020},
doi = {10.1002/dad2.12052},
pmid = {32743041},
url = {https://doi.org/10.1002/dad2.12052}
}
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Key findings
- We included 201 individuals (mean age 73.5 years, mean BMI 27.4 kg/m2).
- Higher BMI was related to less cortical thickness and higher metabolism in brain areas typically not involved in AD (family-wise error [FWE] <0.05), but not to AD CSF biomarkers.
- It is notable that the impact of obesity on brain metabolism and structure was also found in amyloid negative individuals.
- CONCLUSIONS/ In the cognitively unimpaired elderly, obesity has differential effects on brain metabolism and structure independent of an underlying AD pathophysiology.
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Study details
- Participants201
- Evidence strengthLow
How this study scored 52/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 29 of the 56 points we could judge it on, which is 52 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (Amsterdam, Netherlands)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 201 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32743041) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 29 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 29 of the 56 points we could judge it on is 52 out of 100. |
| Total | 52 / 100 | — |
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