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Mitochondrial Dysfunction and Alzheimer's Disease: Role of Microglia
Agrawal I, Jha S.. Frontiers in aging neuroscience, 2020-08-20
Topic: Amyloid, tau and blood-test diagnosis
In 1907, Alois Alzheimer observed, as he quoted, development of "numerous fibers" and "adipose saccules" in the brain of his diseased patient Auguste Deter. The neurodegenerative disease became known as Alzheimer's disease (AD) and is the most common cause of dementia worldwide. AD normally develops with aging and is mostly initiated because of the imbalance between the formation and clearance of amyloid-β (Aβ).
Key findings
- The neurodegenerative disease became known as Alzheimer's disease (AD) and is the most common cause of dementia worldwide.
- AD normally develops with aging and is mostly initiated because of the imbalance between the formation and clearance of amyloid-β (Aβ).
- Formation of neurofibrillary tangles (NFTs) of hyperphosphorylated tau is another hallmark of AD.
- Neuroinflammation plays a significant role in the development and pathology of AD.
Why it matters
This review discusses how mitochondrial dysfunction, neuroinflammation, amyloid-beta imbalance, and tau tangles contribute to Alzheimer's disease, with a focus on the role of microglia. It summarizes proposed disease mechanisms and does not present a proven treatment, cure, or prevention.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in aging neuroscience) |
| Journal's citation record | 2 / 4 | Frontiers in Aging Neuroscience: journal h-index 174 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 181 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 22.6 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 4 / 6 | Cited 8.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 3 / 4 | Cited 77 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Sushmita Jha: h-index 21 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Indian Institute of Technology Jodhpur: institution h-index 154 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32973488) |
| Free to read | 2 / 2 | Free to read |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3389/fnagi.2020.00252
- PubMed: 32973488
- Original source →
- Free full text: Frontiers in Aging Neuroscience →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Agrawal, I., & Jha, S. (2020). Mitochondrial Dysfunction and Alzheimer's Disease: Role of Microglia. Frontiers in aging neuroscience. https://doi.org/10.3389/fnagi.2020.00252
Vancouver
Agrawal I, Jha S. Mitochondrial Dysfunction and Alzheimer's Disease: Role of Microglia. Frontiers in aging neuroscience. 2020. doi:10.3389/fnagi.2020.00252. PMID: 32973488.
BibTeX
@article{agrawal2020-32973488,
author = {Agrawal, I. and Jha, S.},
title = {{Mitochondrial Dysfunction and Alzheimer's Disease: Role of Microglia}},
journal = {Frontiers in aging neuroscience},
year = {2020},
doi = {10.3389/fnagi.2020.00252},
pmid = {32973488},
url = {https://doi.org/10.3389/fnagi.2020.00252}
}
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