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Subjective Cognitive Decline, Cognitive Reserve Indicators, and the Incidence of Dementia
Feifei Jia, Yanyan Li, Min Li, Fenglin Cao. Journal of the American Medical Directors Association, 2020-09-20
Topic: Brain imaging, connectivity and assessment
Baseline subjective cognitive decline and low cognitive reserve significantly increased the risk of dementia, after 2 years of follow-up. There was an additive interaction between subjective cognitive decline and cognitive reserve [the relative excess risk due to interaction = -0.63, 95% confidence interval (CI) = -0.89 to -0.36, P for additive interaction <0.001]. There was no multiplicative interaction between subjective cognitive decline and cognitive reserve indicator (P = .138). Statistically significant association between subjective cognitive decline and dementia was found only in the low-level and medium-level cognitive reserve group (OR = 3.78, 95% CI = 1.50-9.55 and OR = 3.64, 95% CI = 1.09-12.2, respectively), but not in the high-level groups. CONCLUSION AND Cognitive reserve attenuated subjective cognitive decline associated risk of developing dementia. This finding suggests the need for greater emphasis on detecting prodromal dementia when older patients having lower cognitive reserve present with subjective cognitive decline.
Key findings
- Baseline subjective cognitive decline and low cognitive reserve significantly increased the risk of dementia, after 2 years of follow-up.
- There was an additive interaction between subjective cognitive decline and cognitive reserve [the relative excess risk due to interaction = -0.63, 95% confidence interval (CI) = -0.89 to -0.36, P for additive interaction <0.001].
- There was no multiplicative interaction between subjective cognitive decline and cognitive reserve indicator (P = .138).
- Statistically significant association between subjective cognitive decline and dementia was found only in the low-level and medium-level cognitive reserve group (OR = 3.78, 95% CI = 1.50-9.55 and OR = 3.64, 95% CI = 1.09-12.2, respectively), but not in the high-level groups.
- CONCLUSION AND Cognitive reserve attenuated subjective cognitive decline associated risk of developing dementia.
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Study details
- Study designlongitudinal study
- Participants2,099
- Effect sizeOR = 3.78; OR = 3.64
- Evidence strengthModerate
How this study scored 73/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 41 of the 56 points we could judge it on, which is 73 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the American Medical Directors Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 3 / 4 | 2,099 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32967819) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 41 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 41 of the 56 points we could judge it on is 73 out of 100. |
| Total | 73 / 100 | — |
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APA 7th
Jia, F., Li, Y., Li, M., & Cao, F. (2021). Subjective Cognitive Decline, Cognitive Reserve Indicators, and the Incidence of Dementia. Journal of the American Medical Directors Association. https://doi.org/10.1016/j.jamda.2020.08.005
Vancouver
Jia F, Li Y, Li M, Cao F. Subjective Cognitive Decline, Cognitive Reserve Indicators, and the Incidence of Dementia. Journal of the American Medical Directors Association. 2021. doi:10.1016/j.jamda.2020.08.005. PMID: 32967819.
BibTeX
@article{jia2021-32967819,
author = {Jia, Feifei and Li, Yanyan and Li, Min and Cao, Fenglin},
title = {{Subjective Cognitive Decline, Cognitive Reserve Indicators, and the Incidence of Dementia}},
journal = {Journal of the American Medical Directors Association},
year = {2021},
doi = {10.1016/j.jamda.2020.08.005},
pmid = {32967819},
url = {https://doi.org/10.1016/j.jamda.2020.08.005}
}