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A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease
Preuss C, Pandey R, Piazza E, Fine A, Uyar A, Perumal T, Garceau D, Kotredes KP et al.. Molecular neurodegeneration, 2020-11-10
Topic: Amyloid, tau and blood-test diagnosis
Background Late-onset Alzheimer's disease (LOAD) is the most common form of dementia worldwide. To date, animal models of Alzheimer's have focused on rare familial mutations, due to a lack of frank neuropathology from models based on common disease genes. Recent multi-cohort studies of postmortem human brain transcriptomes have identified a set of 30 gene co-expression modules associated with LOAD, providing a molecular catalog of relevant endophenotypes.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Preuss, C., Pandey, R., Piazza, E., Fine, A., Uyar, A., Perumal, T., et al. (2020). A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease. Molecular neurodegeneration. https://doi.org/10.1186/s13024-020-00412-5
Vancouver
Preuss C, Pandey R, Piazza E, Fine A, Uyar A, Perumal T, et al. A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease. Molecular neurodegeneration. 2020. doi:10.1186/s13024-020-00412-5. PMID: 33172468.
BibTeX
@article{preuss2020-33172468,
author = {Preuss, C. and Pandey, R. and Piazza, E. and Fine, A. and Uyar, A. and Perumal, T. and Garceau, D. and Kotredes, K. P. and others},
title = {{A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease}},
journal = {Molecular neurodegeneration},
year = {2020},
doi = {10.1186/s13024-020-00412-5},
pmid = {33172468},
url = {https://doi.org/10.1186/s13024-020-00412-5}
}
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Key findings
- To date, animal models of Alzheimer's have focused on rare familial mutations, due to a lack of frank neuropathology from models based on common disease genes.
- Recent multi-cohort studies of postmortem human brain transcriptomes have identified a set of 30 gene co-expression modules associated with LOAD, providing a molecular catalog of relevant endophenotypes.
- Results This resource enables precise gene-based alignment between new animal models and human molecular signatures of disease.
- Here, we describe a new resource to efficiently screen mouse models for LOAD relevance.
Why it matters
This work presents a systems biology approach to compare mouse models of late-onset Alzheimer's disease with human brain gene expression modules associated with the disease. It is a research tool for aligning animal models with human molecular signatures, not a treatment, cure or prevention.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Study designcohort study
- Evidence strengthModerate
How this study scored 54/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Molecular neurodegeneration) |
| Journal's citation record | 2 / 4 | Molecular Neurodegeneration: journal h-index 164 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “mouse”) — scores zero |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 64 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.0 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 3 / 6 | Cited 5.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 2 / 4 | Cited 24 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Gregory W. Carter: h-index 30 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Indiana University School of Medicine: institution h-index 784 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33172468) |
| Free to read | 2 / 2 | Free to read |
| Total | 54 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s13024-020-00412-5
- PubMed: 33172468
- Original source →
- Free full text: Molecular Neurodegeneration →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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