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Home-based multimodal exercise program in older people with Alzheimer disease: Randomized controlled trial protocol
Cezar NOC, Ansai JH, de Andrade LP.. Physiotherapy research international : the journal for researchers and clinicians in physical therapy, 2021-02-15
Topic: Amyloid, tau and blood-test diagnosis
Background At-home physical exercise may be an important intervention strategy for older people with Alzheimer disease (AD) due to the greater adherence and ease for the caregivers. Purpose Determine the effects home-based multimodal exercise program in older people with AD on muscle strength, balance, functioning, cognition, dual task performance, frailty, and physical activity level. Methods This is a trial with 40 older people with mild and moderate AD, randomized into intervention group (IG) and control group (CG). The participants will be evaluated by blinded examiners at baseline and after 16 weeks of training. The evaluations will investigate functioning (Timed Up and Go test, Direct Assessment of Functional Status, WHO Disability Assessment Schedule, Short Physical Performance Battery, and Activities of Daily Living Questionnaire), muscle strength (manual dynamometer and Sit-to-Stand test), frailty (FRAIL Scale and Edmonton Frail Scale), cognition (Addenbrooke's Cognitive Examination, Trail Making Test, Walking Trail-Making Test, and Frontal Assessment Battery), balance (force platform, Figure-of-Eight Walking Test, Functional Reach Test, Alternate Step Test, and Calf-Raise Senior), dual task (force platform), and physical activity level (Modified Baecke Questionnaire and Life-Space Assessment). The IG will perform 16 weeks of exercise at home that involve functioning, strength, balance, and aerobic endurance in 60-min sessions three times a week. The CG will not undergo any intervention. Conclusion Improvements in the aspects evaluated are expected in the IG compared to CG. The protocol will provide a theoretical basis for the creation of clinical interventions and health promotion measures for older people with AD.
Key findings
- Conclusion Improvements in the aspects evaluated are expected in the IG compared to CG.
Why it matters
This is a protocol for a 40-person trial testing a 16-week home-based exercise program in people with mild to moderate Alzheimer's disease. No results are available yet; the authors only state that improvements are expected in the exercise group.
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Study details
- Evidence strengthHigh
How this study scored 37/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and studied in people because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Physiotherapy research international : the journal for researchers and clinicians in physical therapy) |
| Journal's citation record | 0 / 4 | Physiotherapy Research International: journal h-index 74 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | 2 / 7 | Cited 10 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.4 citations a year over 7 year(s) since 2021 |
| Impact for its field and year | 2 / 6 | Cited 1.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Larissa Pires de Andrade: h-index 24 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Universidade Federal de São Carlos: institution h-index 272 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33586858) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 37 / 100 | — |
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Read the original
May need a subscription Unpaywall, Europe PMC and OpenAlex found no free copy of the full text (checked 10 Oct 2026), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Cezar, N. O. C., Ansai, J. H., & de Andrade, L. P. (2021). Home-based multimodal exercise program in older people with Alzheimer disease: Randomized controlled trial protocol. Physiotherapy research international : the journal for researchers and clinicians in physical therapy. https://doi.org/10.1002/pri.1899
Vancouver
Cezar NOC, Ansai JH, de Andrade LP. Home-based multimodal exercise program in older people with Alzheimer disease: Randomized controlled trial protocol. Physiotherapy research international : the journal for researchers and clinicians in physical therapy. 2021. doi:10.1002/pri.1899. PMID: 33586858.
BibTeX
@article{cezar2021-33586858,
author = {Cezar, N. O. C. and Ansai, J. H. and de Andrade, L. P.},
title = {{Home-based multimodal exercise program in older people with Alzheimer disease: Randomized controlled trial protocol}},
journal = {Physiotherapy research international : the journal for researchers and clinicians in physical therapy},
year = {2021},
doi = {10.1002/pri.1899},
pmid = {33586858},
url = {https://doi.org/10.1002/pri.1899}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.