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52/100

✓ Peer-reviewed alzhub usefulness score 52 out of 100. Tau biomarkers

Topic: Brain proteins, microglia and lab models

Importance In vivo biomarkers for detecting neuropathologies from repetitive head impacts (RHI), including chronic traumatic encephalopathy (CTE), are needed. Objective To evaluate the utility of plasma phosphorylated tau 217 (p-tau217), assess its performance as a beta-amyloid (Aβ) biomarker in participants with RHI exposure at risk for CTE, and explore concordance with CTE neuropathology in a postmortem subsample. Design, setting, and participants This longitudinal, multicenter, case-control study used data from the Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation of CTE (DIAGNOSE CTE) Research Project, collected from September 2016 to October 2023.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Miner, A. E., Zetterberg, H., Blennow, K., Groh, JR., Singh, A., Dieckhoff, K., et al. (2026). Plasma Phosphorylated Tau 217 in Participants at Risk for Chronic Traumatic Encephalopathy. JAMA network open. https://doi.org/10.1001/jamanetworkopen.2026.22966

Vancouver

Miner AE, Zetterberg H, Blennow K, Groh JR, Singh A, Dieckhoff K, et al. Plasma Phosphorylated Tau 217 in Participants at Risk for Chronic Traumatic Encephalopathy. JAMA network open. 2026. doi:10.1001/jamanetworkopen.2026.22966. PMID: 42440317.

BibTeX

@article{miner2026-42440317,
  author  = {Miner, A. E. and Zetterberg, H. and Blennow, K. and Groh, JR. and Singh, A. and Dieckhoff, K. and Tripodis, Y. and Adler, C. H. and others},
  title   = {{Plasma Phosphorylated Tau 217 in Participants at Risk for Chronic Traumatic Encephalopathy}},
  journal = {JAMA network open},
  year    = {2026},
  doi     = {10.1001/jamanetworkopen.2026.22966},
  pmid    = {42440317},
  url     = {https://doi.org/10.1001/jamanetworkopen.2026.22966}
}

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Key findings

Objective To evaluate the utility of plasma phosphorylated tau 217 (p-tau217), assess its performance as a beta-amyloid (Aβ) biomarker in participants with RHI exposure at risk for CTE, and explore concordance with CTE neuropathology in a postmortem subsample.
Design, setting, and participants This longitudinal, multicenter, case-control study used data from the Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation of CTE (DIAGNOSE CTE) Research Project, collected from September 2016 to October 2023.
Participants were former American football players (case participants) and asymptomatic men unexposed to RHI (control participants).
A subsample had available neuropathologic data.

Why it matters

This longitudinal multicenter case-control study evaluated plasma p-tau217 as a biomarker in people with repetitive head impacts at risk for chronic traumatic encephalopathy, including a postmortem subsample. It is about detecting a different condition and does not show a way to treat, cure, or prevent Alzheimer's disease.

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Study details

Study designcase-control study
Participants231
Evidence strengthModerate

How this study scored 52/100

Published in a leading specialty journal, and it is a case-control study. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 50 of the 96 points we could judge it on, which is 52 out of 100.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA network open)
Journal's citation record	2 / 4	JAMA Network Open: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	6 / 12	A case-control study
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	2 / 4	231 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 2 year(s) since 2026
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	OpenAlex's profile for last-listed author Aaron Ritter holds only 7 work(s), too few to judge a track record — left out of this score
Institution's track record	3 / 3	University of Washington: institution h-index 3,540 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 36 institution(s) in 5 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 42440317)
Free to read	2 / 2	Free to read
Points	50 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 50 of the 96 points we could judge it on is 52 out of 100.
Total	52 / 100	—

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Read the original

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