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[Consistency evaluation of the domestic Lifotronic platform and foreign luminescence platforms in detecting core cerebrospinal fluid biomarkers in Chinese Alzheimer disease patients]
Tian C, Wang ZY, Liu SY, Kang XX, Yu ZW, Pan DH, Guo Z, Qiao HW et al.. Zhonghua yi xue za zhi, 2026-07-01
Topic: Amyloid, tau and blood-test diagnosis
Objective: To evaluate the consistency of measurement results and diagnostic agreement of core cerebrospinal fluid (CSF) biomarkers for Alzheimer disease (AD) in a Chinese population, which were measured across a domestically developed electrochemiluminescence platform (Lifotronic eCL8000), a Japanese chemiluminescence immunoassay platform (LUMIPULSE), and an American electrochemiluminescence platform (Meso Scale Discovery, MSD). Methods: CSF samples were retrospectively collected from 253 subjects recruited at Peking Union Medical College Hospital, Xuanwu Hospital Capital Medical University, and Beijing Tiantan Hospital between July 2013 and September 2019. The cohort was comprised of 132 males and 121 females, with the age of (62.4±13.3) years.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Tian, C., Wang, Z. Y., Liu, S. Y., Kang, X. X., Yu, Z. W., Pan, D. H., et al. (2026). [Consistency evaluation of the domestic Lifotronic platform and foreign luminescence platforms in detecting core cerebrospinal fluid biomarkers in Chinese Alzheimer disease patients]. Zhonghua yi xue za zhi. https://doi.org/10.3760/cma.j.cn112137-20260414-01014
Vancouver
Tian C, Wang ZY, Liu SY, Kang XX, Yu ZW, Pan DH, et al. [Consistency evaluation of the domestic Lifotronic platform and foreign luminescence platforms in detecting core cerebrospinal fluid biomarkers in Chinese Alzheimer disease patients]. Zhonghua yi xue za zhi. 2026. doi:10.3760/cma.j.cn112137-20260414-01014. PMID: 42402882.
BibTeX
@article{tian2026-42402882,
author = {Tian, C. and Wang, Z. Y. and Liu, S. Y. and Kang, X. X. and Yu, Z. W. and Pan, D. H. and Guo, Z. and Qiao, H. W. and others},
title = {{[Consistency evaluation of the domestic Lifotronic platform and foreign luminescence platforms in detecting core cerebrospinal fluid biomarkers in Chinese Alzheimer disease patients]}},
journal = {Zhonghua yi xue za zhi},
year = {2026},
doi = {10.3760/cma.j.cn112137-20260414-01014},
pmid = {42402882},
url = {https://doi.org/10.3760/cma.j.cn112137-20260414-01014}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Methods: CSF samples were retrospectively collected from 253 subjects recruited at Peking Union Medical College Hospital, Xuanwu Hospital Capital Medical University, and Beijing Tiantan Hospital between July 2013 and September 2019.
- The cohort was comprised of 132 males and 121 females, with the age of (62.4±13.3) years.
- All CSF samples were collected via standardized protocols and cryopreserved at -80 ℃.
- Inter-assay repeatability (coefficient of variation, CV) of the Lifotronic platform on different days was validated.
Why it matters
Using cerebrospinal fluid from 253 subjects, this study evaluated whether a domestic Lifotronic platform, a Japanese LUMIPULSE platform, and an American Meso Scale Discovery platform gave consistent results for core Alzheimer's disease cerebrospinal fluid biomarkers. It is a measurement comparison and does not test treatment, cure, or prevention.
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Study details
- Participants253
- Effect size99.60%
- Evidence strengthModerate
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it. We have no data on journal's citation record, impact for its field and year and senior author's track record, so those were left out: it earned 37 of the 86 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Zhonghua yi xue za zhi) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 2 / 4 | 253 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author J Zhang holds only 1 work(s), too few to judge a track record — left out of this score |
| Institution's track record | 1 / 3 | Zhejiang University: institution h-index 1,040 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 42402882) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 37 / 86 | Scored on 17 of 20 parts. We have no data for the rest, so they are left out: 37 of the 86 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
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