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Association Between Midlife Obesity and Its Metabolic Consequences, Cerebrovascular Disease, and Cognitive Decline
Morys F, Dadar M, Dagher A.. The Journal of clinical endocrinology and metabolism, 2021-09-01
Topic: Risk, prevention and care in population studies
Context Chronic obesity is associated with several complications, including cognitive impairment and dementia. However, we have only piecemeal knowledge of the mechanisms linking obesity to central nervous system damage. Among candidate mechanisms are other elements of obesity-associated metabolic syndrome, such as hypertension, dyslipidemia, and diabetes, but also systemic inflammation.
Key findings
- However, we have only piecemeal knowledge of the mechanisms linking obesity to central nervous system damage.
- Among candidate mechanisms are other elements of obesity-associated metabolic syndrome, such as hypertension, dyslipidemia, and diabetes, but also systemic inflammation.
- While there have been several neuroimaging studies linking adiposity to changes in brain morphometry, a comprehensive investigation of the relationship has so far not been done.
- Objective To identify links between adiposity and cognitive dysfunction.
Why it matters
This study investigated possible links between midlife obesity, its metabolic consequences such as hypertension and diabetes, cerebrovascular disease, and cognitive decline. It is an observational cohort study that may help identify risk factors but does not test any treatment, cure, or prevention.
Study details
- Study designcohort study
- Evidence strengthModerate
How this study scored 60/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The Journal of clinical endocrinology and metabolism) |
| Journal's citation record | 3 / 4 | The Journal of Clinical Endocrinology & Metabolism: journal h-index 490 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 168 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 24.0 citations a year over 7 year(s) since 2021 |
| Impact for its field and year | 4 / 6 | Cited 15.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 3 / 4 | Cited 105 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Alain Dagher: h-index 85 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | McGill University: institution h-index 1,373 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33677592) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 60 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1210/clinem/dgab135
- PubMed: 33677592
- Original source →
- Free full text: bioRxiv (Cold Spring Harbor Laboratory) →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Morys, F., Dadar, M., & Dagher, A. (2021). Association Between Midlife Obesity and Its Metabolic Consequences, Cerebrovascular Disease, and Cognitive Decline. The Journal of clinical endocrinology and metabolism. https://doi.org/10.1210/clinem/dgab135
Vancouver
Morys F, Dadar M, Dagher A. Association Between Midlife Obesity and Its Metabolic Consequences, Cerebrovascular Disease, and Cognitive Decline. The Journal of clinical endocrinology and metabolism. 2021. doi:10.1210/clinem/dgab135. PMID: 33677592.
BibTeX
@article{morys2021-33677592,
author = {Morys, F. and Dadar, M. and Dagher, A.},
title = {{Association Between Midlife Obesity and Its Metabolic Consequences, Cerebrovascular Disease, and Cognitive Decline}},
journal = {The Journal of clinical endocrinology and metabolism},
year = {2021},
doi = {10.1210/clinem/dgab135},
pmid = {33677592},
url = {https://doi.org/10.1210/clinem/dgab135}
}
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