Home › Research › Inflammation and the immune system
Autophagy in Alzheimer's disease pathogenesis: Therapeutic potential and future perspectives
Zhang Z, Yang X, Song YQ, Tu J.. Ageing research reviews, 2021-09-20
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease (AD) is a complex neurodegenerative disease in the elderly and the most common cause of human dementia. AD is characterized by accumulation of abnormal protein aggregates including amyloid plaques (composed of beta-amyloid (Aβ) peptides) and neurofibrillary tangles (formed by hyper-phosphorylated tau protein). Synaptic plasticity, neuroinflammation, calcium signaling etc. also show dysfunction in AD patients.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zhang, Z., Yang, X., Song, Y. Q., & Tu, J. (2021). Autophagy in Alzheimer's disease pathogenesis: Therapeutic potential and future perspectives. Ageing research reviews. https://doi.org/10.1016/j.arr.2021.101464
Vancouver
Zhang Z, Yang X, Song YQ, Tu J. Autophagy in Alzheimer's disease pathogenesis: Therapeutic potential and future perspectives. Ageing research reviews. 2021. doi:10.1016/j.arr.2021.101464. PMID: 34551326.
BibTeX
@article{zhang2021-34551326,
author = {Zhang, Z. and Yang, X. and Song, Y. Q. and Tu, J.},
title = {{Autophagy in Alzheimer's disease pathogenesis: Therapeutic potential and future perspectives}},
journal = {Ageing research reviews},
year = {2021},
doi = {10.1016/j.arr.2021.101464},
pmid = {34551326},
url = {https://doi.org/10.1016/j.arr.2021.101464}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- AD is characterized by accumulation of abnormal protein aggregates including amyloid plaques (composed of beta-amyloid (Aβ) peptides) and neurofibrillary tangles (formed by hyper-phosphorylated tau protein).
- Synaptic plasticity, neuroinflammation, calcium signaling etc. also show dysfunction in AD patients.
- Autophagy is an evolutionarily conserved lysosome-dependent cellular event in eukaryotes.
- It is closely linked to modulation of protein metabolism, through which damaged organelles and mis-folded proteins are degraded and then recycled to maintain protein homeostasis.
Why it matters
This review describes autophagy as a lysosome-dependent cellular process linked to protein metabolism, and notes that Alzheimer's disease involves accumulation of amyloid plaques and hyper-phosphorylated tau tangles. It discusses autophagy as a potential therapeutic direction but reports no demonstrated treatment, cure or prevention.
Study details
- Evidence strengthLow
How this study scored 51/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Ageing research reviews) |
| Journal's citation record | 2 / 4 | Ageing Research Reviews: journal h-index 225 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 369 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 52.7 citations a year over 7 year(s) since 2021 |
| Impact for its field and year | 4 / 6 | Cited 10.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 4 / 4 | Cited 279 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Jie Tu: h-index 18 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Chinese Academy of Sciences: institution h-index 1,801 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34551326) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 51 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.arr.2021.101464
- PubMed: 34551326
- Original source →
- Free full text: Ageing Research Reviews →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Related
Studies in the library that share something with this one. The line above each title says what.
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 19.
Later studies that cite this one
8 studies in the alzhub library list this one in their references.
Related studies in Inflammation and the immune system
Also in Inflammation and the immune system
138 studies in the library are filed under Inflammation and the immune system with no topic tag they share with another; these are this study's neighbours in a fixed tour of them. The Inflammation and the immune system hub.