Topic: Brain imaging, connectivity and assessment
Agitation days showed higher median sample entropy (1.23 vs 1.06; p<0.001) and approximate entropy (1.24 vs 1.08; p<5 × 10−19). Seven-day pre-event sample entropy mean 1.18 vs control 1.08 (Cohen d=0.42). Hurst exponent was lower on agitation days (median 0.68 vs 0.73), suggesting reduced long-range persistence during disruption. Approximate entropy showed the strongest effect across health-event types. Pre-agitation signal is robust across entropy families but not uniform: irregularity metrics rise while persistence metrics fall. Feature anatomy supports the [10] choice of multifeature sequences rather than single-metric triggers.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Khadka, R., & Samjhana. (2026). Entropy Anatomy of Pre-Agitation Activity Disruption in the TIHM Home-Monitoring Cohort. Research Square. https://doi.org/10.21203/rs.3.rs-10362909/v1
Vancouver
Khadka R, Samjhana. Entropy Anatomy of Pre-Agitation Activity Disruption in the TIHM Home-Monitoring Cohort. Research Square. 2026. doi:10.21203/rs.3.rs-10362909/v1.
BibTeX
@article{khadka2026-eab8d261,
author = {Khadka, R. and Samjhana},
title = {{Entropy Anatomy of Pre-Agitation Activity Disruption in the TIHM Home-Monitoring Cohort}},
journal = {Research Square},
year = {2026},
doi = {10.21203/rs.3.rs-10362909/v1},
url = {https://doi.org/10.21203/rs.3.rs-10362909/v1}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Agitation days showed higher median sample entropy (1.23 vs 1.06; p<0.001) and approximate entropy (1.24 vs 1.08; p<5 × 10−19).
- Seven-day pre-event sample entropy mean 1.18 vs control 1.08 (Cohen d=0.42).
- Hurst exponent was lower on agitation days (median 0.68 vs 0.73), suggesting reduced long-range persistence during disruption.
- Approximate entropy showed the strongest effect across health-event types.
- Pre-agitation signal is robust across entropy families but not uniform: irregularity metrics rise while persistence metrics fall.
Study details
- Participants114
- Evidence strengthModerate
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 32 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 20 of the 62 points we could judge it on, which is 32 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (Research Square) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 2 / 4 | 114 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 20 / 62 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 20 of the 62 points we could judge it on is 32 out of 100. |
| Total | 32 / 100 | Capped to 16 because this is not a peer-reviewed article. |
What each of these 20 components measures, and what this score is not →
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