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Associations of [ 18 F]PI-2620 Binding with Memory and Phosphorylated Tau 217 in Cognitively Unimpaired Older Adults
Anne Maaß, Berta Garcia‐Garcia, Niklas Behrenbruch, Beate Schumann‐Werner, Eóin N. Molloy, Svenja Schwarck, Michael Rullmann, Anne Hochkeppler et al.. Journal of Nuclear Medicine, 2026-07-16
Topic: Brain proteins, microglia and lab models
In older adults, temporal [18F]PI-2620 binding was higher in women (β = 0.543, P < 0.001) and APOE4 carriers (β = 0.395, P = 0.030) and was positively associated with plasma p-tau217 (β = 0.22, P = 0.008). Voxelwise analyses showed age-related increases in basal ganglia signal, whereas WM signal was higher in younger adults. In a multiple regression model, higher temporal DVR (β = −0.36, P = 0.003) and lower hippocampal volume (β = 0.22, P = 0.007) predicted worse episodic memory and, together with demographic factors, explained approximately 30% of the variance. Temporal [18F]PI-2620 binding is associated with genetic AD risk, plasma p-tau217, female sex, and episodic memory deficits in CU older adults, supporting its sensitivity to early tau pathology, while highlighting the need to consider potential WM binding.
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APA 7th
Maaß, A., Garcia‐Garcia, B., Behrenbruch, N., Schumann‐Werner, B., Molloy, E. N., Schwarck, S., et al. (2026). Associations of [ 18 F]PI-2620 Binding with Memory and Phosphorylated Tau 217 in Cognitively Unimpaired Older Adults. Journal of Nuclear Medicine. https://doi.org/10.2967/jnumed.125.271927
Vancouver
Maaß A, Garcia‐Garcia B, Behrenbruch N, Schumann‐Werner B, Molloy EN, Schwarck S, et al. Associations of [ 18 F]PI-2620 Binding with Memory and Phosphorylated Tau 217 in Cognitively Unimpaired Older Adults. Journal of Nuclear Medicine. 2026. doi:10.2967/jnumed.125.271927. PMID: 42463287.
BibTeX
@article{maass2026-42463287,
author = {Maaß, Anne and Garcia‐Garcia, Berta and Behrenbruch, Niklas and Schumann‐Werner, Beate and Molloy, Eóin N. and Schwarck, Svenja and Rullmann, Michael and Hochkeppler, Anne and others},
title = {{Associations of [ 18 F]PI-2620 Binding with Memory and Phosphorylated Tau 217 in Cognitively Unimpaired Older Adults}},
journal = {Journal of Nuclear Medicine},
year = {2026},
doi = {10.2967/jnumed.125.271927},
pmid = {42463287},
url = {https://doi.org/10.2967/jnumed.125.271927}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- In older adults, temporal [18F]PI-2620 binding was higher in women (β = 0.543, P < 0.001) and APOE4 carriers (β = 0.395, P = 0.030) and was positively associated with plasma p-tau217 (β = 0.22, P = 0.008).
- Voxelwise analyses showed age-related increases in basal ganglia signal, whereas WM signal was higher in younger adults.
- In a multiple regression model, higher temporal DVR (β = −0.36, P = 0.003) and lower hippocampal volume (β = 0.22, P = 0.007) predicted worse episodic memory and, together with demographic factors, explained approximately 30% of the variance.
- Temporal [18F]PI-2620 binding is associated with genetic AD risk, plasma p-tau217, female sex, and episodic memory deficits in CU older adults, supporting its sensitivity to early tau pathology, while highlighting the need to consider potential WM binding.
Why it matters
In cognitively unimpaired older adults, higher temporal [18F]PI-2620 binding was associated with genetic AD risk, plasma p-tau217, female sex, and worse episodic memory. This supports the tracer's sensitivity to early tau pathology but does not test any treatment, cure, or prevention.
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Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Nuclear Medicine) |
| Journal's citation record | 2 / 4 | Journal of Nuclear Medicine: journal h-index 230 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.5 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 3 / 6 | Cited 4.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Emrah Düzel: h-index 90 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Edinburgh: institution h-index 1,378 (OpenAlex) |
| Multicenter collaboration | 3 / 3 | OpenAlex lists 12 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 42463287) |
| Free to read | 2 / 2 | Free to read |
| Total | 40 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.2967/jnumed.125.271927
- PubMed: 42463287
- Original source →
- Free full text: Journal of Nuclear Medicine →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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