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Home › Research › Getting a diagnosis

Episodic memory ERPs reflect preclinical Alzheimer’s disease progression

Raposo Pereira F, Chaumon M, Dubois B, Bakardjian H, Andrade K, Habert M, Younsi N, La Corte V et al.. bioRxiv, 2026-07-17

This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Getting a diagnosis

Topic: Brain imaging, connectivity and assessment

Structured Abstract Background Alzheimer’s disease (AD) neuropathology emerges decades before symptoms, requiring sensitive, non-invasive markers for early diagnosis. We investigated behavioural and EEG markers of episodic memory in cognitively normal older adults at-risk for AD. Methods Forty-five INSIGHT-preAD cohort participants (15 progressors to prodromal AD, 15 stable β-amyloid positive [Aβ+] participants, 15 controls [Aβ-]) completed an Old/New word recognition task during high-density EEG. Behavioural performance and memory-related evoked-related potentials (ERPs; P3, FN400, P600, post-retrieval monitoring) were analysed longitudinally over 5 years. Results Progressors showed significantly reduced accuracy, sensitivity, and slower responses. They showed attenuated FN400, P600, and monitoring amplitudes over left parieto-occipital regions. Source analysis revealed hypoactivation in the left inferior frontal and right posterior cingulate cortex, across components with additional disruption during P600. Stable Aβ+ individuals showed milder P600 hypoactivations. Discussion Behavioural and ERP alterations preceded clinical decline, supporting EEG-based markers of episodic memory decline for preclinical AD risk stratification.

Key findings

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Study details

How this study scored 16/100
How this study's score is builtJournal tier 2 of 10; Journal's citation record 0 of 4; Study design 0 of 12; Strength of evidence 3 of 5; Peer-review validation 4 of 10; How recent 5 of 5; Sample size 0 of 4; Effect reported 0 of 3; Studied in people 0 of 3; Randomised / blinded 0 of 2; Times cited left out, no data; Citations per year left out, no data; Impact for its field and year left out, no data; Cited by studies here left out, no data; Still being cited left out, no data; Senior author's track record left out, no data; Institution's track record left out, no data; Multi-centre collaboration left out, no data; Indexed in PubMed 1 of 2; Free to read 0 of 2. 15 of the 62 points it could be judged on, which is 24 of 100. Raw total 24 of 100, shown as 16 because this is not a peer-reviewed research article.raw total 24 of 100capped at 16 — hatched points do not count

Preprint — not yet peer-reviewed. It scored 24 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 15 of the 62 points we could judge it on, which is 24 out of 100.

ComponentPointsWhy
Journal tier 2 / 10 Tier 4 — not a peer-reviewed journal (bioRxiv)
Journal's citation record 0 / 4 Not a journal article, so the journal's record does not count
Study design 0 / 12 No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence 3 / 5 Rated “moderate” in our summary
Peer-review validation 4 / 10 Preprint — not yet peer-reviewed. Hosted on a preprint server.
How recent 5 / 5 2026 — within 1 year(s) of the newest study here
Sample size 0 / 4 Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported 0 / 3 No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people 0 / 3 Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded 0 / 2 No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited — / 7 No citation count (not found in OpenAlex) — left out of this score
Citations per year — / 5 No citation count or no year — left out of this score
Impact for its field and year — / 6 No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here — / 6 Not yet checked against this library's citation graph — left out of this score
Still being cited — / 4 No yearly citation counts — left out of this score
Senior author's track record — / 4 Senior author's record not available — left out of this score
Institution's track record — / 3 No institution listed in OpenAlex — left out of this score
Multi-centre collaboration — / 3 Institutions not listed — left out of this score
Indexed in PubMed 1 / 2 Not in PubMed, but has a DOI
Free to read 0 / 2 Behind a paywall — scores zero
Points 15 / 62 Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 15 of the 62 points we could judge it on is 24 out of 100.
Total 24 / 100 Capped to 16 because this is not a peer-reviewed article.

What each of these 20 components measures, and what this score is not →

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Raposo Pereira, F., Chaumon, M., Dubois, B., Bakardjian, H., Andrade, K., Habert, M., et al. (2026). Episodic memory ERPs reflect preclinical Alzheimer’s disease progression. bioRxiv. https://doi.org/10.64898/2026.07.11.737503

Vancouver

Raposo Pereira F, Chaumon M, Dubois B, Bakardjian H, Andrade K, Habert M, et al. Episodic memory ERPs reflect preclinical Alzheimer’s disease progression. bioRxiv. 2026. doi:10.64898/2026.07.11.737503.

BibTeX

@article{raposopereira2026-c6276936,
  author  = {Raposo Pereira, F. and Chaumon, M. and Dubois, B. and Bakardjian, H. and Andrade, K. and Habert, M. and Younsi, N. and La Corte, V. and others},
  title   = {{Episodic memory ERPs reflect preclinical Alzheimer’s disease progression}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.11.737503},
  url     = {https://doi.org/10.64898/2026.07.11.737503}
}

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