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A Blood Test for Alzheimer's Disease: It's about Time or Not Ready for Prime Time?
Douglas R Galasko, Joshua D Grill, Jennifer H Lingler, Judith L Heidebrink, Symptomatic Subcommittee of the Advisory Group on Risk Evidence Education for Dementia (AGREEDementia). Journal of Alzheimer's disease : JAD, 2022
Topic: Plasma and spinal-fluid biomarkers
Plain-language summary
A blood test for Alzheimer's disease is now available for clinical use in persons with cognitive impairment. This is an extraordinary milestone, though the amyloid-based PrecivityAD™ test is not without limitations. Pre and post-test counseling are essential. Phosphorylated tau blood tests are likely to follow soon. When used in conjunction with an appropriate clinical evaluation, blood tests provide the opportunity for an early, accurate, and accessible diagnosis of Alzheimer's disease. Standalone use, however, carries a significant risk of misinterpretation and is strongly discouraged. Now is the time to develop appropriate use criteria to guide the use of these promising assays.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Galasko, D. R., Grill, J. D., Lingler, J. H., & Heidebrink, J. L. (2022). A Blood Test for Alzheimer's Disease: It's about Time or Not Ready for Prime Time? Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-215490
Vancouver
Galasko DR, Grill JD, Lingler JH, Heidebrink JL. A Blood Test for Alzheimer's Disease: It's about Time or Not Ready for Prime Time? Journal of Alzheimer's disease : JAD. 2022. doi:10.3233/jad-215490. PMID: 35147543.
BibTeX
@article{galasko2022-35147543,
author = {Galasko, Douglas R and Grill, Joshua D and Lingler, Jennifer H and Heidebrink, Judith L},
title = {{A Blood Test for Alzheimer's Disease: It's about Time or Not Ready for Prime Time?}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2022},
doi = {10.3233/jad-215490},
pmid = {35147543},
url = {https://doi.org/10.3233/jad-215490}
}
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Key findings
- Standalone use, however, carries a significant risk of misinterpretation and is strongly discouraged.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 23 of the 56 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35147543) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 23 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 23 of the 56 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
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