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Associations of Physical Activity with Alzheimer's Disease Pathologies and Cognition: The CABLE Study
Shuang Zhong, Bing Zhao, Ya-Hui Ma, Yan Sun, Yong-Li Zhao, Wen-Hui Liu, Ya-Nan Ou, Qiang Dong et al.. Journal of Alzheimer's disease : JAD, 2022
Topic: Brain imaging, connectivity and assessment
Regular physical activity was positively associated with CSF Aβ42 (p < 0.001) and Aβ42/40 (p < 0.001), while it was negatively associated with p-tau/Aβ42 (p < 0.001) and t-tau/Aβ42 (p < 0.001). Of all participants, regular physical activity was associated with increased cognitive function (p < 0.001). The interaction effect indicated that age moderated the association between physical activity frequency and CSF Aβ42 (p = 0.014) and p-tau/Aβ42 (p = 0.041). The impact of physical activity on cognition was mediated in part by amyloid pathologies, accounting for 4.87% to 21.56% of the total effect (p < 0.05). This study showed the beneficial impact of physical activity on AD pathologies and cognition in participants without dementia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zhong, S., Zhao, B., Ma, Y.-H., Sun, Y., Zhao, Y.-L., Liu, W.-H., et al. (2022). Associations of Physical Activity with Alzheimer's Disease Pathologies and Cognition: The CABLE Study. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-220389
Vancouver
Zhong S, Zhao B, Ma Y.-H, Sun Y, Zhao Y.-L, Liu W.-H, et al. Associations of Physical Activity with Alzheimer's Disease Pathologies and Cognition: The CABLE Study. Journal of Alzheimer's disease : JAD. 2022. doi:10.3233/jad-220389. PMID: 35871345.
BibTeX
@article{zhong2022-35871345,
author = {Zhong, Shuang and Zhao, Bing and Ma, Ya-Hui and Sun, Yan and Zhao, Yong-Li and Liu, Wen-Hui and Ou, Ya-Nan and Dong, Qiang and others},
title = {{Associations of Physical Activity with Alzheimer's Disease Pathologies and Cognition: The CABLE Study}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2022},
doi = {10.3233/jad-220389},
pmid = {35871345},
url = {https://doi.org/10.3233/jad-220389}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Regular physical activity was positively associated with CSF Aβ42 (p < 0.001) and Aβ42/40 (p < 0.001), while it was negatively associated with p-tau/Aβ42 (p < 0.001) and t-tau/Aβ42 (p < 0.001).
- Of all participants, regular physical activity was associated with increased cognitive function (p < 0.001).
- The interaction effect indicated that age moderated the association between physical activity frequency and CSF Aβ42 (p = 0.014) and p-tau/Aβ42 (p = 0.041).
- The impact of physical activity on cognition was mediated in part by amyloid pathologies, accounting for 4.87% to 21.56% of the total effect (p < 0.05).
- This study showed the beneficial impact of physical activity on AD pathologies and cognition in participants without dementia.
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Study details
- Study designcross-sectional
- Participants918
- Effect sizeor 4.87; 21.56%
- Evidence strengthLow
How this study scored 61/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 34 of the 56 points we could judge it on, which is 61 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 918 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35871345) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 34 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 34 of the 56 points we could judge it on is 61 out of 100. |
| Total | 61 / 100 | — |
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